Mechanics of Uterosacral Ligaments: Current Knowledge, Existing Gaps, and Future Directions
Mechanics of Uterosacral Ligaments: Current Knowledge, Existing Gaps, and Future Directions
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DOI：
10.1007/s10439-021-02755-6
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发表时间：
2021-03-22
影响因子：
3.8
通讯作者：
De Vita, Raffaella
中科院分区：
文献类型：
--
作者：
Donaldson, Kandace;Huntington, Alyssa;De Vita, Raffaella
子宫骶韧带（USLs）是骨盆内支撑子宫和阴道根尖的重要解剖结构。由于这些结构过度拉伸，变得脆弱，并表现出松弛，盆底疾病，如盆腔器官脱垂发生。虽然有几种治疗盆底疾病的外科手术是针对usl的，但它们的功能仍有很多未知之处。这篇文章介绍了目前关于超塑性硅溶胶力学性能的知识。本文首先综述了usl的解剖、微观结构和临床意义。然后，对已发表的体内和离体、单轴和双轴拉伸试验的实验研究结果进行汇总。在现有研究成果的基础上，指出了研究空白，并对未来的研究方向进行了讨论。这个详尽的回顾的目的是帮助新的研究人员浏览科学文献的机械性能的超声激光器。这些结构的使用在重建手术中仍然非常流行，以恢复和增加骨盆器官的支持，特别是在合成手术网状植入物仍然存在高度争议的情况下。
The uterosacral ligaments (USLs) are important anatomical structures that support the uterus and apical vagina within the pelvis. As these structures are over-stretched, become weak, and exhibit laxity, pelvic floor disorders such as pelvic organ prolapse occur. Although several surgical procedures to treat pelvic floor disorders are directed toward the USLs, there is still a lot that is unknown about their function. This manuscript presents a review of the current knowledge on the mechanical properties of the USLs. The anatomy, microstructure, and clinical significance of the USLs are first reviewed. Then, the results of published experimental studies on the in vivo and ex vivo, uniaxial and biaxial tensile tests are compiled. Based on the existing findings, research gaps are identified and future research directions are discussed. The purpose of this exhaustive review is to help new researchers navigate scientific literature on the mechanical properties of the USLs. The use of these structures remains very popular in reconstructive surgeries that restore and augment the support of pelvic organs, especially as synthetic surgical mesh implants continue to be highly controversial.