Smaller volume of right hippocampal CA2/3 in patients with panic disorder
Smaller volume of right hippocampal CA2/3 in patients with panic disorder
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DOI：
10.1007/s11682-020-00259-w
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发表时间：
2020-03-03
影响因子：
3.2
通讯作者：
Hirayasu, Yoshio
中科院分区：
文献类型：
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作者：
Takaishi, Masao;Asami, Takeshi;Hirayasu, Yoshio
海马被认为在向杏仁核传递背景信息方面起着重要作用，杏仁核是惊恐障碍（PD）的神经基础。先前的研究已经揭示了与健康对照受试者（HC）相比，PD患者海马的功能异常，但没有研究报告海马的体积异常或评估此类患者海马的微小结构变化。因此，我们研究了海马子区域的体积异常，以更好地了解PD的神经生物学基础。从38例PD和38例HC患者的结构脑磁共振图像中提取海马，然后分割成6个子场。比较两组各子野的相对体积。使用惊恐障碍严重程度量表（PDSS）评估症状的严重程度，并使用整体功能评估（GAF）量表评估社会功能。我们的研究结果显示，PD患者的右角氨（CA）2/3海马子区的体积明显小于HC。在相关分析中，未发现右侧CA 2/3体积与PDSS或GAF评分之间存在显著相关性。总之，CA 2/3被认为是与上下文记忆功能，我们的研究结果表明，这个特定的海马子区发挥了作用，在PD症状的发展。
The hippocampus is thought to play an important role in conveying contextual information to the amygdala as the neural basis of panic disorder (PD). Previous studies have revealed functional abnormalities in the hippocampus in patients with PD compared with healthy control subjects (HC), but no study has reported volume abnormalities in the hippocampus or evaluated minute structural changes in the hippocampus in such patients. We thus investigated volume abnormalities in the subfields of the hippocampus to better understand the neurobiological basis of PD. The hippocampus was extracted from structural brain magnetic resonance images obtained from 38 patients with PD and 38 HC and then segmented into six subfields. The relative volume of each subfield was compared between the two groups. The severity of symptoms was assessed using the Panic Disorder Severity Scale (PDSS) and social functioning was assessed using the Global Assessment of Functioning (GAF) scale. Our results revealed that patients with PD had a significantly smaller volume of the right cornu ammonis (CA) 2/3 hippocampal subfield compared with HC. No significant associations were found between the volumes of the right CA 2/3 and the PDSS or GAF scores in correlation analyses. In conclusion, CA2/3 is thought to be related to contextual memory function, and our results suggest that this particular hippocampal subfield plays a role in the development of PD symptoms.