INVIVO C-13 NUCLEAR MAGNETIC-RESONANCE STUDIES OF MAMMALS
INVIVO C-13 NUCLEAR MAGNETIC-RESONANCE STUDIES OF MAMMALS
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DOI：
10.1126/science.7292005
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
HANLEY, PE
中科院分区：
文献类型：
--
作者：
ALGER, JR;SILLERUD, LO;HANLEY, PE
在体内观察了人手臂和大鼠组织中天然丰度的~(13)C核磁共振。这些信号主要来自脂肪组织中的甘油三酯。在活体大鼠体内，~(13)C核磁共振也被用来跟踪被引入胃中的C-1标记的葡萄糖到C-1标记的肝糖原的转化。~(13)C的灵敏度和分辨率表明，天然丰度的~(13)C核磁共振在脂肪代谢紊乱的研究中将是有价值的，用~(13)C标记底物的实验可以用于体内碳水化合物代谢的研究。
Natural abundance 13C NMR from human arm and rat tissues were observed in vivo. These signals arise primarily from triglycerides in fatty tissue. 13C NMR was also used to follow, in a living rat, the conversion of C-1-labeled glucose, which was introduced into the stomach, to C-1-labeled liver glycogen. The 13C sensitivity and resolution obtained shows that natural abundance 13C NMR will be valuable in the study of disorders in fat metabolism and that experiments with substrates labeled with 13C can be used to study carbohydrate metabolism in vivo.