Rickettsia rickettsii induces superoxide radical and superoxide dismutase in human endothelial cells.
Rickettsia rickettsii induces superoxide radical and superoxide dismutase in human endothelial cells.
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立克次体在人内皮细胞中诱导超氧化自由基和超氧化歧化酶。
DOI：
10.1128/iai.60.12.5113-5118.1992
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发表时间：
1992
影响因子：
3.1
通讯作者：
Silverman,DJ
中科院分区：
文献类型：
--
作者：
Santucci,LA;Gutierrez,PL;Silverman,DJ
Human endothelial cells infected with Rickettsia rickettsii, the etiological agent of Rocky Mountain spotted fever, undergo striking morphological changes to the endoplasmic reticulum-outer nuclear envelope complex. These changes are accompanied by concurrent accumulation of intracellular peroxides. Both of these findings are consistent with the notion that cells undergo some form of oxidative stress. Since oxidant injury is often initiated or mediated through oxygen radicals, we examined superoxide radical generation when endothelial cells were exposed to R. rickettsii. We also examined the levels of superoxide dismutase, an enzyme induced in response to increased superoxide formation. The levels of both superoxide and superoxide dismutase increased when endothelial cells were exposed to R. rickettsii. These results, together with our previous findings, support our hypothesis that cells infected by this intracellular bacterium experience oxidant-mediated injury that may eventually contribute to cell death.
