Profiles of recent autobiographical memory retrieval in semantic dementia, behavioural-variant frontotemporal dementia, and Alzheimer's disease
Profiles of recent autobiographical memory retrieval in semantic dementia, behavioural-variant frontotemporal dementia, and Alzheimer's disease
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DOI：
10.1016/j.neuropsychologia.2011.05.017
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发表时间：
2011-07-01
期刊：
影响因子：
2.6
通讯作者：
Piguet, O.
中科院分区：
文献类型：
--
作者：
Irish, M.;Hornberger, M.;Piguet, O.
情景自传体记忆（ABM）包括对特定时空背景下发生的事件的回忆，通常伴随着感知和情感信息。介导ABM检索的神经基质是那些在语义性痴呆（SD）和行为变异性额颞叶痴呆（bvFTD）（FTD的最常见亚型）中具有显著病理学的神经基质。然而，我们对这些痴呆综合征在发作性ABM检索过程中上下文细节的差异模式知之甚少。本研究调查了4个时间段在自由回忆和探测回忆条件下的情景ABM检索，旨在确定情景ABM上下文细节的疾病特异性特征。在25例SD和15例bvFTD患者中测量了发作性ABM，并将其表现与17例阿尔茨海默病（AD）患者和19例年龄匹配的对照进行了对比。很严重。SD患者表现出相对保存近期ABM与远程时期相比。相比之下，bvFTD和AD患者在自由回忆和探索回忆条件下，在所有生命阶段回忆特定和背景丰富ABM的能力降低。最近一段时间（过去12个月）的分析提供了证据，不同的配置文件的背景情节细节回忆痴呆综合征。在探测之后，SD患者的回忆缺陷完全来自于受损的情绪/思想和时空细节。相比之下，bvFTD患者在所有类别的背景细节方面均显著受损，而AD患者仅在事件和情绪/想法细节方面表现出缺陷。作为迄今为止FTD中最大的ABM研究，这些结果强调了近期ABM背景细节的差异性损害取决于基础疾病病理学。此外，这些结果指向调查的重要性，情绪处理和战略检索过程的潜在变量介导最近的情景ABM检索的组成要素。(C)2011爱思唯尔有限公司保留所有权利。
Episodic autobiographical memory (ABM) comprises recollection for events that are grounded within a specific spatiotemporal context, and usually accompanied by perceptual and emotional information. The neural substrates mediating ABM retrieval are those harbouring significant pathology in semantic dementia (SD) and behavioural-variant frontotemporal dementia (bvFTD), the most common subtypes of FTD. Relatively little is known, however, regarding the differential patterns of contextual details during episodic ABM retrieval across these dementia syndromes. This study investigated episodic ABM retrieval under free and probed recall conditions from 4 time periods with the aim to identify disease-specific profiles of episodic ABM contextual details. Episodic ABM was measured in 25 SD and 15 bvFTD patients and their performance contrasted to that of 17 Alzheimer's disease (AD) patients and 19 age-matched controls. Critically. SD patients showed relatively preserved recent ABM in comparison with remote epochs. In contrast, bvFTD and AD patients showed a reduced capacity to recall specific and contextually rich ABMs across all life epochs, in both free and probed recall conditions. Analyses of the recent period (last 12 months) provided evidence for different profiles of contextual episodic details recalled in dementia syndromes. Following probing, SD patients' recall deficits emanated exclusively from compromised Emotion/Thoughts and Spatiotemporal details. In contrast, bvFTD patients were significantly impaired across all categories of contextual details whereas AD patients showed deficits for Event and Emotion/Thoughts details only. As the largest study of ABM in FTD to date, these findings emphasise the differential impairment of recent ABM contextual details contingent on the underlying disease pathology. In addition, these results point towards the importance of investigating the constituent elements of emotion processing and strategic retrieval processes as potential variables mediating recent episodic ABM retrieval. (C) 2011 Elsevier Ltd. All rights reserved.