Identify the Prognostic and Immune Profile of VSIR in the Tumor Microenvironment: A Pan-Cancer Analysis.
Identify the Prognostic and Immune Profile of VSIR in the Tumor Microenvironment: A Pan-Cancer Analysis.
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确定肿瘤微环境中 VSIR 的预后和免疫特征：泛癌症分析
DOI：
10.3389/fcell.2022.821649
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
VSIR是一种重要的免疫调节受体，可抑制T细胞效应功能并维持外周耐受。然而，VSIR在泛癌肿瘤微环境中参与肿瘤免疫的机制仍不清楚。本研究系统地探讨了VSIR在33种癌症的肿瘤微环境中的预后和免疫特征。我们比较了VSIR在正常和肿瘤组织中的表达模式和分子特征。VSIR水平与患者的预后显著相关，并可能是许多肿瘤类型（如GBM、KIRC、SKCM、READ和PRAD）的有希望的预测因子。VSIR升高与肿瘤微环境中浸润的炎性细胞、新抗原表达、MSI、TMB和经典免疫检查点密切相关。富集信号通路分析表明VSIR参与了成纤维细胞、T细胞、肥大细胞、巨噬细胞和泡沫细胞的活化、增殖和迁移等免疫相关通路。此外，基于单细胞测序分析发现VSIR广泛表达于多种肿瘤类型的癌细胞、成纤维细胞、巨噬细胞和T细胞上，并且基于免疫荧光染色发现VSIR与M2巨噬细胞标志物CD 68、CD 163共表达。最后对VSIR的敏感药物及VSIR的免疫学价值进行了预测。总之，VSIR水平与多种癌症类型的临床结果和肿瘤免疫力密切相关。因此，靶向肿瘤微环境中的VSIR的治疗策略可能是癌症免疫治疗的有价值的工具。
VSIR is a critical immunomodulatory receptor that inhibits T cell effector function and maintains peripheral tolerance. However, the mechanism by which VSIR participates in tumor immunity in the pan-cancer tumor microenvironment remains unclear. This study systematically explored the prognostic and immune profile of VSIR in the tumor microenvironment of 33 cancers. We compared the expression patterns and molecular features of VSIR in the normal and cancer samples both from the public databases and tumor chips. VSIR level was significantly related to patients’ prognosis and could be a promising predictor in many tumor types, such as GBM, KIRC, SKCM, READ, and PRAD. Elevated VSIR was closely correlated with infiltrated inflammatory cells, neoantigens expression, MSI, TMB, and classical immune checkpoints in the tumor microenvironment. Enrichment signaling pathways analysis indicated VSIR was involved in several immune-related pathways such as activation, proliferation, and migration of fibroblast, T cell, mast cell, macrophages, and foam cell. In addition, VSIR was found to widely express on cancer cells, fibroblasts, macrophages, and T cells in many tumor types based on the single-cell sequencing analysis and co-express with M2 macrophage markers CD68, CD163 based on the immunofluorescence staining. Finally, we predicted the sensitive drugs targeting VSIR and the immunotherapeutic value of VSIR. In sum, VSIR levels strongly correlated with the clinical outcome and tumor immunity in multiple cancer types. Therefore, therapeutic strategies targeting VSIR in the tumor microenvironment may be valuable tools for cancer immunotherapy.
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影响因子：
11.2
作者：
Le Mercier I;Chen W;Lines JL;Day M;Li J;Sergent P;Noelle RJ;Wang L
通讯作者：
Wang L
影响因子：
51.1
作者：
Arnold, Melina;Rutherford, Mark J.;Bray, Freddie
通讯作者：
Bray, Freddie
影响因子：
3.4
作者：
Bang, Yung-Jue;Kang, Yoon-Koo;Kang, Won K.;Boku, Narikazu;Chung, Hyun C.;Chen, Jen-Shi;Doi, Toshihiko;Sun, Yan;Shen, Lin;Qin, Shukui;Ng, Wai-Tong;Tursi, Jennifer M.;Lechuga, Maria J.;Lu, Dongrui Ray;Ruiz-Garcia, Ana;Sobrero, Alberto
通讯作者：
Sobrero, Alberto
DOI：
10.1136/bmj.j4530
发表时间：
2017-10-04
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Davis C;Naci H;Gurpinar E;Poplavska E;Pinto A;Aggarwal A
通讯作者：
Aggarwal A
DOI：
10.1007/s40267-018-0482-6
发表时间：
2018
期刊：
Drugs & therapy perspectives : for rational drug selection and use
影响因子：
--
作者：
Deeks ED;Keating GM
通讯作者：
Keating GM