Complications of bacteriologically confirmed typhoid fever in children
Complications of bacteriologically confirmed typhoid fever in children
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DOI：
10.1093/tropej/48.2.102
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发表时间：
2002-04-01
影响因子：
2
通讯作者：
Malik, AS
中科院分区：
文献类型：
--
作者：
Malik, AS
为了了解伤寒并发症的发生率、标志物和性质，我们在一项历时近 5 年的横断面研究中对 102 名伤寒沙门氏菌培养呈阳性的儿童进行了前瞻性研究。所有分离株均对常用抗生素敏感。这些儿童中有三分之一出现并发症，包括：无黄疸型肝炎、骨髓抑制、麻痹性肠梗阻、心肌炎、精神病、胆囊炎、骨髓炎、腹膜炎、肺炎、溶血和抗利尿激素释放不当综合征（SIADH）。十二名儿童出现了多种并发症。如果将肝炎排除在并发症之外，经细菌学确诊的伤寒病例的并发症发生率将降至 11%。这些并发症与以下因素无关：患者的年龄或性别、入院前病程、入院前使用抗生素、营养状况、“O”或“H”滴度水平、IgM 或 IgG 抗体的存在、或氯霉素或氨苄青霉素治疗。患有脾肿大、血小板减少或白细胞减少的儿童更容易出现并发症。
To find the incidence, markers and nature of complications of typhoid fever, we studied 102 children with cultures positive for Salmonella typhi in a cross-sectional study, prospectively, over a period of almost 5 years. All isolates were sensitive to commonly used antibiotics. One third of these children developed complications which included: anicteric hepatitis, bone marrow suppression, paralytic ileus, myocarditis, psychosis, cholecystitis, osteomyelitis, peritonitis, pneumonia, haemolysis, and syndrome of inappropriate release of antidiuretic hormone (SIADH). Twelve children developed multiple complications. If hepatitis is excluded from the complications, the rate of complications in bacteriologically confirmed cases of typhoid fever drops to 11 per cent. These complications were not related to: the age or sex of patients, duration of illness before admission, use of antibiotics before admission, nutritional status, level of 'O' or 'H' titre, presence of IgM or IgG antibodies, or treatment with chloramphenicol or ampicillin. Children with splenomegaly, thrombocytopenia or leukopenia were more likely to develop complications.