Adiposity distribution influences circulating adiponectin levels.
Adiposity distribution influences circulating adiponectin levels.
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DOI：
10.1016/j.trsl.2014.04.008
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Kidambi S
中科院分区：
文献类型：
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作者：
Guenther M;James R;Marks J;Zhao S;Szabo A;Kidambi S
百分之三十的肥胖个体代谢健康，并且注意到周围性肥胖有所增加。脂肪组织是脂联素的主要来源，脂联素是一种具有胰岛素增敏和抗炎特性的脂肪因子。在肥胖者和有心血管疾病风险的人中观察到脂联素水平较低。相反，一些代谢健康的肥胖个体的水平较高。我们的目的是确定腹部脂肪分布（而不是 BMI 状态）是否影响血浆脂联素水平。 424 名具有北欧血统的受试者（女性：255 名）是从“Take Off Pounds Sensously”（TOPS）减肥俱乐部成员中招募的。进行全身人口统计学、人体测量、双X射线吸收测量和腹部CT扫描，以获得全身脂肪含量，并分别量化皮下脂肪组织和内脏脂肪组织。实验室测量包括空腹血糖、胰岛素、血脂和脂联素。年龄和性别调整相关分析显示，脂联素水平与体重指数、腰围、甘油三酯、总脂肪量和内脏脂肪组织呈负相关。与 HDL-胆固醇和去脂质量呈正相关 (p<0.05)。皮下脂肪组织与内脏脂肪组织的比率也与脂联素显着相关（r=0.13，p=0.001）。此外，通过回归分析发现，血浆脂联素的最佳阳性预测因子是皮下脂肪组织与内脏脂肪组织的比率和性别（P<0.01）。腹部脂肪分布是血浆脂联素的重要预测因子，皮下脂肪组织与内脏脂肪组织比率较高的肥胖个体可能具有较高的脂联素水平。
Thirty percent of obese individuals are metabolically healthy and were noted have increased peripheral obesity. Adipose tissue is the primary source of adiponectin, an adipokine with insulin-sensitizing and anti-inflammatory properties. Lower adiponectin levels are observed in individuals with obesity and those at risk for cardiovascular disease. Conversely, higher levels are noted in some obese individuals who are metabolically healthy. Our objective was to determine whether abdominal adiposity distribution, rather than BMI status, influences plasma adiponectin level. Four-hundred and twenty-four subjects (female: 255) of Northern European ancestry were recruited from “Take Off Pounds Sensibly” (TOPS) weight loss club members. Demographics, anthropometrics, and dual X-ray absorptiometry of the whole body and CT scan of the abdomen were performed to obtain total body fat content and to quantify subcutaneous adipose tissue and visceral adipose tissue respectively. Laboratory measurements included fasting plasma glucose, insulin, lipid panel, and adiponectin. Age- and gender-adjusted correlation analyses showed that adiponectin levels were negatively correlated with body mass index, waist circumference, triglycerides, total fat mass, and visceral adipose tissue. A positive correlation was noted with HDL-cholesterol and fat free mass (p<0.05). Subcutaneous adipose tissue -to-visceral adipose tissue ratios were also significantly associated with adiponectin (r=0.13, p = 0.001). Further, the best positive predictors for plasma adiponectin were found to be subcutaneous adipose tissue -to-visceral adipose tissue ratios and gender by regression analyses (P<0.01). Abdominal adiposity distribution is an important predictor of plasma adiponectin and obese individuals with higher subcutaneous adipose tissue -to-visceral adipose tissue ratios may have higher adiponectin levels.