Effect of a Low-Glycemic Index or a High-Cereal Fiber Diet on Type 2 Diabetes A Randomized Trial
Effect of a Low-Glycemic Index or a High-Cereal Fiber Diet on Type 2 Diabetes A Randomized Trial
复制标题
DOI：
10.1001/jama.2008.808
复制
发表时间：
2008-12-17
影响因子：
120.7
通讯作者：
Leiter, Lawrence A.
中科院分区：
文献类型：
--
作者：
Jenkins, David J. A.;Kendall, Cyril W. C.;Leiter, Lawrence A.
背景：使用降糖药物改善血糖控制的临床试验并未显示预期的心血管益处。低血糖指数饮食可以改善2型糖尿病患者的血糖控制和心血管危险因素，但由于试验的局限性，对其有效性的争论仍在继续。在加拿大大学医院研究中心进行的平行研究设计，210名接受降糖药物治疗的2型糖尿病患者通过报纸广告招募，并在2004年9月16日之间随机分配接受2种饮食治疗中的1种，干预高谷物纤维或低血糖指数的饮食建议。主要结果测量糖化血红蛋白A（1c）（HbA（1c））的绝对变化，以空腹血糖和心血管疾病危险因素作为次要指标。结果在意向治疗分析中，HbA（1c）绝对HbA（1c）单位降低- 0.18%（95%置信区间[ CI]，-0.29%至-0.07%），与绝对HbA（1c）单位-0.50%相比（95%CI，-0.61%至-0.39%）低血糖指数饮食组（P
Context Clinical trials using antihyperglycemic medications to improve glycemic control have not demonstrated the anticipated cardiovascular benefits. Low - glycemic index diets may improve both glycemic control and cardiovascular risk factors for patients with type 2 diabetes but debate over their effectiveness continues due to trial limitations.Objective To test the effects of low - glycemic index diets on glycemic control and cardiovascular risk factors in patients with type 2 diabetes.Design, Setting, and Participants A randomized, parallel study design at a Canadian university hospital research center of 210 participantswith type 2 diabetes treated with antihyperglycemic medications who were recruited by newspaper advertisement and randomly assigned to receive 1 of 2 diet treatments each for 6 months between September 16, 2004, and May 22, 2007.Intervention High - cereal fiber or low - glycemic index dietary advice.Main Outcome Measures Absolute change in glycated hemoglobin A(1c) (HbA(1c)), with fasting blood glucose and cardiovascular disease risk factors as secondary measures.Results In the intention-to-treat analysis, HbA(1c) decreased by - 0.18% absolute HbA(1c) units ( 95% confidence interval [ CI], - 0.29% to - 0.07%) in the high - cereal fiber diet compared with - 0.50% absolute HbA(1c) units ( 95% CI, - 0.61% to - 0.39%) in the low - glycemic index diet ( P