Partial reversal of anticholinergic amnesia by choline chloride.
Partial reversal of anticholinergic amnesia by choline chloride.
复制标题
氯化胆碱可部分逆转抗胆碱能遗忘症。
DOI：
10.1016/0024-3205(81)90674-3
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发表时间：
1981
期刊：
影响因子：
6.1
通讯作者：
Levy,MI
中科院分区：
文献类型：
--
作者：
Mohs,RC;Davis,KL;Levy,MI
20名年轻成年男性在接受氯胆碱加东莨菪碱、安慰剂加东莨菪碱和两种安慰剂后，按随机顺序在不同的日子接受记忆和情绪测试。东莨菪碱在口头学习任务中的表现明显受损。用胆碱预处理导致这种损伤虽小但显著减少，并部分逆转了东莨菪碱引起的情绪变化。虽然之前的一些研究未能证明单独给予胆碱对认知有显著影响，但本研究结果表明胆碱可以在胆碱能阻断的条件下增强认知。这与临床前数据一致，表明胆碱能神经元在快速放电时对前体可用性最敏感。
Twenty young adult males were given tests of memory and mood after receiving choline chloride plus scopolamine, placebo plus scopolamine, and two placebos on separate days in randomized order. Scopolamine caused a marked impairment in performance on a verbal learning task. Pretreatment with choline caused a small but significant decrease in this impairment and partially reversed the mood changes produced by scopolamine. Although several previous studies have failed to demonstrate that choline has a significant effect on cognition when given alone, the present results indicate that choline can enhance cognition under conditions of cholinergic blockade. This is consistent with preclinical data indicating that cholinergic neurons are most sensitive to precursor availability when they are firing rapidly.