Maternal Folate and Cobalamin Status Predicts Vitamin Status in Newborns and 6-Month-Old Infants
Maternal Folate and Cobalamin Status Predicts Vitamin Status in Newborns and 6-Month-Old Infants
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DOI：
10.3945/jn.109.117424
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发表时间：
2010-03-01
影响因子：
4.2
通讯作者：
Refsum, Helga
中科院分区：
文献类型：
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作者：
Hay, Gry;Clausen, Torun;Refsum, Helga
本纵向研究的目的是确定婴儿期叶酸和钴胺素状况的预测因子。数据收集自364对母亲-婴儿，从怀孕（类似于18周; n = 149），新生儿（脐带血清; n = 361），6个月大的部分或完全母乳喂养的儿童（n = 221）的血液测量。出生时和6个月时的血清/血浆叶酸、钴胺素、全转钴胺素（holoTC）、全结合咕啉（holoHC）、甲基丙二酸（MMA）和总同型半胱氨酸（tHcy）与母亲维生素状态、产次、生活方式变量和人体测量学有关。在多变量分析中，出生时和6个月时叶酸的最强预测因素分别是母体叶酸和脐带叶酸（P < 0.01）。母体总胆固醇最能预测出生时的钴胺素状态（与脐带钴胺素、总胆固醇和总胆固醇呈正相关;与MMA和tHcy呈负相关; P
Our aim in this longitudinal study was to determine predictors of folate and cobalamin status in infancy. Data were collected from 364 mother-infant pairs with blood measurements from pregnancy (similar to 18 wk; n = 149), newborns (cord serum; n = 361), and 6-mo-old partially or exclusively breast-fed children (n = 221). Serum/plasma folate, cobalamin, holotranscobalamin (holoTC), holohaptocorrin (holoHC), methylmalonic acid (MMA) and total homocysteine (tHcy) at birth and 6 mo were related to maternal vitamin status, parity, lifestyle variables, and anthropometry. In multivariate analyses, the strongest predictors of folate at birth and 6 mo were maternal folate and cord folate, respectively (P < 0.01). Maternal holoTC best predicted cobalamin status at birth (positively associated with cord cobalamin, holoTC, and holoHC; inversely with MMA and tHcy; P