Magnesium intake and incidence of pancreatic cancer: the VITamins and Lifestyle study.
Magnesium intake and incidence of pancreatic cancer: the VITamins and Lifestyle study.
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DOI：
10.1038/bjc.2015.382
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发表时间：
2015-12-01
影响因子：
8.8
通讯作者：
He K
中科院分区：
文献类型：
--
作者：
Dibaba D;Xun P;Yokota K;White E;He K
研究表明，镁与糖尿病的风险呈负相关，糖尿病是胰腺癌的危险因素。然而，关于镁与胰腺癌直接相关性的研究很少，研究结果也不确定。在这项研究中，我们的目的是在一项大型前瞻性队列研究中调查镁摄入量与胰腺癌发病率之间的纵向关联。2000年至2008年，对参与维生素与生活方式（VITAL）研究的66806名基线年龄在50-76岁之间的男性和女性进行了跟踪。采用多变量校正的考克斯回归模型，按镁摄入类别估计胰腺癌发病率的风险比（HR）和95%置信区间（CI）。在平均6.8年的随访中，151名参与者患上了胰腺癌。与镁摄入量达到推荐膳食供给量（RDA）的受试者相比，镁摄入量在75- 99%RDA范围内的受试者胰腺癌的多变量校正HR（95%CI）为1.42（0.91，2.21），镁摄入量<75%RDA的受试者为1.76（1.04，2.96）。镁摄入量每天每减少100 mg，胰腺癌发病率增加24%（HR：1.24; 95% CI：1.02，1.50; P趋势=0.03）。所观察到的负相关似乎没有明显的年龄，性别，体重指数和非甾体抗炎药的使用，但似乎仅限于那些服用镁补充剂（从多种维生素或个人补充）。这项前瞻性队列研究的结果表明，镁摄入量可能有利于胰腺癌的一级预防。
Studies document that magnesium is inversely associated with the risk of diabetes, which is a risk factor of pancreatic cancer. However, studies on the direct association of magnesium with pancreatic cancer are few and findings are inconclusive. In this study, we aimed to investigate the longitudinal association between magnesium intake and pancreatic cancer incidence in a large prospective cohort study. A cohort of 66 806 men and women aged 50–76 years at baseline who participated in the VITamins And Lifestyle (VITAL) study was followed from 2000 to 2008. Multivariable-adjusted Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of pancreatic cancer incidence by magnesium intake categories. During an average of 6.8-year follow-up, 151 participants developed pancreatic cancer. Compared with those who met the recommended dietary allowance (RDA) for magnesium intake, the multivariable-adjusted HRs (95% CIs) for pancreatic cancer were 1.42 (0.91, 2.21) for those with magnesium intake in the range of 75–99% RDA and 1.76 (1.04, 2.96) for those with magnesium intake <75% RDA. Every 100 mg per day decrement in magnesium intake was associated with a 24% increase in the incidence of pancreatic cancer (HR: 1.24; 95% CI: 1.02, 1.50; Ptrend=0.03). The observed inverse associations appeared not to be appreciably modified by age, gender, body mass index, and non-steroidal anti-inflammatory drug use but appeared to be limited to those taking magnesium supplementation (from multivitamins or individual supplement). Findings from this prospective cohort study indicate that magnesium intake may be beneficial in terms of primary prevention of pancreatic cancer.