Poor responses to oseltamivir treatment in a patient with influenza A (H7N9) virus infection
Poor responses to oseltamivir treatment in a patient with influenza A (H7N9) virus infection
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DOI：
10.1038/emi2013.30
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发表时间：
2013-05-08
影响因子：
13.2
通讯作者：
Lu, Hongzhou
中科院分区：
文献类型：
--
作者：
Liu, Xuhui;Li, Tao;Lu, Hongzhou
2013年3月，首次报告人感染H7N9亚型甲型流感病例。初步数据表明，H7N9分离株对神经氨酸酶抑制剂敏感，如奥司他韦，这是推荐的治疗选择。4月2日，1例56岁男性患者因发热、咳嗽到我院就诊。他曾与另一名H7N9患者有密切接触史。该患者在照顾其妻子（4月3日确诊的H7N9感染病例死亡）后，于4月2日出现流感样症状。同日，开始奥司他韦（75 mg bid）治疗。通过实时逆转录-聚合酶链反应对咽拭子标本进行H7N9病毒筛查。患者于4月4日住院。4月4日和4月5日的初始样本对H7N9呈阴性。但4月10日采集的标本检测H7N9呈阳性。该结果得到了上海市疾病预防控制中心的确认。截至4月25日我们提交这份报告时，该患者的拭子样本仍呈H7N9阳性。该病例要求提高对H7N9对奥司他韦潜在耐药性的认识。
In March 2013, the cases of human infection with influenza A of H7N9 subtype were first reported. Preliminary data suggested that the H7N9 isolates are sensitive to neuraminidase inhibitors, such as oseltamivir, which is the recommended choice of treatment. On April 2nd, a 56-year-old male patient was presented with fever and cough to our hospital. He had previous history of close contact with another H7N9 patient. After caring for his wife (a confirmed H7N9 infection case died on April 3rd), this patient showed flu like symptoms on April 2nd. On the same day, oseltamivir (75 mg bid) treatment was started. Throat swab specimens were screened for H7N9 virus by real-time reverse transcriptase-polymerase chain reaction. The patient was hospitalized on April 4th. Initial specimens on April 4th and April 5th were negative for H7N9. But the specimen collected on April 10th was tested positive for H7N9. The result was confirmed by Shanghai Municipal Center of Disease Control and Prevention. By April 25th when we submitted this report, swab specimens of this patient were still positive for H7N9. This case calls for increased awareness of potential resistance of H7N9 to oseltamivir.