A human experimental capsaicin model for trigeminal sensitization. Gender-specific differences
A human experimental capsaicin model for trigeminal sensitization. Gender-specific differences
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DOI：
10.1016/j.pain.2005.08.009
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发表时间：
2005-11-01
期刊：
影响因子：
7.4
通讯作者：
Arendt-Nielsen, L
中科院分区：
文献类型：
--
作者：
Gazerani, P;Andersen, OK;Arendt-Nielsen, L
偏头痛在女性（18%）中比在男性（6%）中更常见。女性偏头痛患者的月经期偏头痛发生率也从7%到19%不等。本研究的主要目的是：(1)研究三叉神经致敏实验辣椒素模型的性别差异（一种提出的偏头痛机制）；(2)探讨月经周期的影响。研究人员对28名健康的男女志愿者进行了研究。前额皮内注射辣椒素100 μ g/0.1 ml。对女性（月经期和黄体期）和男性的疼痛强度和分布以及视觉耀斑和异动区（中枢致敏）进行评估。痛觉面积随月经周期变化显著，月经期为19.2 +/- 2.0 cm X min，黄体期为16.4 +/- 0.9 cm X min （P < 0.001）。在这两个阶段，雌性的面积明显大于雄性（14.2 +/- 1.3 cm X min, P < 0.0001）。月经期光斑面积（69.2 +/- 4.2 cm(2)）明显大于黄体期（58.6 +/- 2.1 cm(2)） （P < 0.0001）。在两个阶段，女性的光斑面积均大于男性（44.9 +/- 3.6 cm, P < 0.0001）。刷子诱发的异常痛觉面积在月经期也大于黄体期（P < 0.0001）和男性（P < 0.0001）。辣椒素引起的疼痛分布差异有统计学意义，月经期的反应大于黄体期（P < 0.01），而男性（P < 0.0001）。辣椒素诱导三叉神经致敏，并引起性别特异性感觉和血管运动反应，月经期女性普遍表现出最强的表现。该模型可进一步应用于人类三叉神经致敏机制的探索。(c) 2005年国际疼痛研究协会。Elsevier B.V.版权所有。
Migraine is much more common in women (18%) than in men (6%). Menstrual migraine in female migraineurs also varies from 7 to 19%. The main goals of the present study were (1) to investigate gender specific differences in an experimental capsaicin model of trigeminal sensitization (a proposed mechanism of migraine) and (2) to explore the influence of menstrual cycle phases. Twenty-eight healthy female and male volunteers were studied. Capsaicin (100 mu g/0.1 ml) was injected intradermally to the forehead. Pain intensity and distribution together with the visual flare and allodynic area (central sensitization) were assessed for females (during their menstrual and luteal phases) and for males. Pain area significantly changed across the menstrual cycle with 19.2 +/- 2.0 cm X min at menstrual and 16.4 +/- 0,9 cm X min at luteal phase (P < 0.001). The area was significantly larger in both phases for females compared to males (14.2 +/- 1.3 cm X min, P < 0.0001). Flare area at menstrual phase (69.2 +/- 4.2 cm(2)) was significantly (P < 0.0001) larger than luteal phase (58.6 +/- 2.1 cm(2)). Females, in both phases, showed larger flare area compared to males (44.9 +/- 3.6 cm(2), P < 0.0001). Area of brush-evoked allodynia was also larger at the menstrual phase compared to the luteal phase (P < 0.0001) and males (P < 0.0001). A significant difference was found in the capsaicin-evoked pain distribution with a greater response in menstrual phase compared to the luteal phase (P < 0.01) and men (P < 0.0001). Capsaicin induced trigeminal sensitization and evoked gender specific sensory and vaso-motor responses, with menstruating females generally showing the strongest manifestations. The model may be further applied to explore mechanisms of human trigerninal sensitization. (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.