Effects of Lemon Beverage Containing Citric Acid with Calcium Supplementation on Bone Metabolism and Mineral Density in Postmenopausal Women: Double-Blind 11-Month Intervention Study.
Effects of Lemon Beverage Containing Citric Acid with Calcium Supplementation on Bone Metabolism and Mineral Density in Postmenopausal Women: Double-Blind 11-Month Intervention Study.
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含柠檬酸的柠檬饮料与钙补充剂对绝经后妇女骨代谢和矿物质密度的影响： 为期 11 个月的双盲干预研究。
DOI：
10.1155/2021/8824753
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发表时间：
2021
影响因子：
2.2
通讯作者：
Harada T
中科院分区：
文献类型：
--
作者：
Ikeda H;Iida T;Hiramitsu M;Inoue T;Aoi S;Kanazashi M;Ishizaki F;Harada T
预防绝经后骨质疏松症的一个关键因素是骨代谢加速周转率的衰减。本随机对照研究旨在阐明柠檬饮料与钙（Ca）补充剂的作用，该柠檬饮料利用柠檬酸的螯合作用。通过评估骨矿物质密度（BMD）和骨转换相关生物标志物对骨进行综合评价。79名绝经后妇女参加了为期11个月的连续摄入试验饮料的研究。受试者被分为三组：饮用含有柠檬酸的柠檬饮料并补充钙的人（LECA组），饮用含有柠檬酸的柠檬饮料但不补充钙的人（LE组），以及不饮用测试饮料的人（对照组）。使用双盲方案，LECA和LE组中的受试者每天消耗一瓶含有290 mL测试饮料。LECA组11个月后BMD变化率显著高于对照组和LE组。与其他组相比，LECA组还显示抗酒石酸酸性磷酸酶5 b（TRACP-5 b）（骨吸收标志物）和骨碱性磷酸酶（BAP）的浓度显著降低，与LE组相比，骨钙素（OC）（骨形成标志物）的浓度显著降低。根据我们的研究结果，我们推测，绝经后妇女的骨吸收和骨形成可能会受到抑制，沿着钙吸收的增加，钙吸收是由柠檬酸的螯合作用引起的，与连续摄入含柠檬酸的钙补充柠檬饮料有关，导致高骨代谢周转受到抑制。此外，研究结果提供了关于躯干骨（包括腰椎和股骨近端）BMD维持的信息。
A critical factor for preventing osteoporosis after menopause is attenuation of the accelerated turnover rate of bone metabolism. The present randomized controlled study was conducted to clarify the effects of a lemon beverage with calcium (Ca) supplementation that makes use of the chelating action of citric acid. Comprehensive evaluations of bone were performed by assessments of bone mineral density (BMD) and biomarkers related to bone turnover. Seventy-nine postmenopausal women were enrolled and asked to participate in an 11-month continuous intake of the test beverages. The subjects were divided into three groups: those who consumed a lemon beverage containing citric acid with Ca supplementation (LECA group), those who consumed a lemon beverage containing citric acid without Ca supplementation (LE group), and those who consumed no test beverage (control group). Using a double-blind protocol, subjects in the LECA and LE groups consumed one bottle containing 290 mL of the test beverage each day. The ratio of change in BMD after 11 months was significantly higher in the LECA group as compared to the control and LE groups. The LECA group also showed significant decreases in concentrations of tartrate-resistant acid phosphatase 5b (TRACP-5b), a bone resorption marker, and bone alkaline phosphatase (BAP) as compared to the other groups, as well as a significant decrease in concentration of osteocalcin (OC), a bone formation marker, as compared to the LE group. Based on our findings, we speculated that bone resorption and bone formation in postmenopausal women might be suppressed along with an increase in Ca resorption caused by chelation of citric acid in association with continuous ingestion of a Ca-supplemented lemon beverage containing citric acid, resulting in suppression of high bone metabolic turnover. In addition, the results provide information regarding BMD maintenance in the bones of the trunk, including the lumbar spine and proximal femur.