Treatment of roentogenographically occult endobronchial carcinoma with external beam radiotherapy and intraluminal low dose rate brachytherapy
Treatment of roentogenographically occult endobronchial carcinoma with external beam radiotherapy and intraluminal low dose rate brachytherapy
复制标题
DOI：
10.1016/0360-3016(95)02390-9
复制
发表时间：
1996-03-15
影响因子：
7
通讯作者：
Fujimori, K
中科院分区：
文献类型：
--
作者：
Saito, M;Yokoyama, A;Fujimori, K
目的：进行了一项前瞻性II期研究，以探讨联合外照射和腔内放射治疗X线摄影隐匿性不可手术的支气管内膜癌的治疗结果。方法和材料：41例（均为男性）X线表现为隐匿性支气管内膜癌，进行使用直线加速器X射线的外部射束放射治疗和经由Ir-192细线（1.48GBq）的腔内低剂量率近距离放射治疗的组合。外照射放疗包括40戈伊，分20次，持续4周，而腔内近距离放射治疗包括25戈伊，分5次，持续2.5-5周。近距离放射治疗的剂量参考点根据支气管直径而变化（3-9 mm）。结果：排除2例拒绝支气管镜检查（1例）和仍在治疗（1例），39例患者按计划治疗。到末次腔内近距离放射治疗时，所有病例的内镜均未发现肿瘤;随访时间范围为1-41个月，中位时间为24.5个月。2例复发，随后进行了手术：1例无癌存活，另1例在35个月时死于不受控制的肺癌。在两例给予糖皮质激素和抗生素的病例中观察到放射性肺炎。两人都恢复了工作。其他复发或严重的并发症，从放射迄今尚未观察到。两个或两个以上的原发癌被确定在19个（肺，10个，其他器官，10）的41 patients.Conclusion：外照射放射治疗和腔内近距离放射治疗的联合治疗是有效的X线摄影隐匿性支气管内膜癌与可接受的并发症。
Purpose: A prospective Phase II study was done to investigate the treatment results of combined external beam and intraluminal radiotherapy in roentogenographically occult inoperable endobronchial carcinoma.Methods and Materials: In 41 patients (all male) with roentogenographically occult endobronchial carcinoma, a combination of external beam radiotherapy using linac x-ray and intraluminal low dose rate brachytherapy via Ir-192 thin wire (1.48 GBq) was performed. External beam radiotherapy comprised of 40 Gy in 20 fractions over 4 weeks was carried out, whereas intraluminal brachytherapy consisted of 25 Gy in five fractions over 2.5-5 weeks. The dose reference point for brachytherapy varied (3-9 mm) according to a diameter of the bronchus.Results: Excluding two cases in which bronchoscopy was refused (1) and was still being treatment (1), 39 patients were treated according to plan. By the last intraluminal brachytherapy, no tumor was endoscopically identifiable in all cases; The follow-up period ranged from 1-41 months, with a median of 24.5 months. Recurrence occurred in two cases, with subsequent surgery: one is alive without cancer and the other died of uncontrolled lung cancer at 35 months. Radiation pneumonitis was observed in two cases for whom glucocorticoid and antibiotics were administered. Both recovered and resumed work. Other recurrences or severe complications from irradiation have not been observed so far. Two or more separate primary cancers were identified in 19 (lung, 10; other organs, 10) of the 41 patients.Conclusion: The combination treatment of external beam radiotherapy and intraluminal brachytherapy is effective for roentogenographically occult endobronchial carcinoma with acceptable complications.