Model for self-polarization and motility of keratocyte fragments
Model for self-polarization and motility of keratocyte fragments
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DOI：
10.1098/rsif.2011.0433
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发表时间：
2012-05
影响因子：
3.9
通讯作者：
F. Ziebert;S. Swaminathan;I. Aranson
中科院分区：
文献类型：
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作者：
F. Ziebert;S. Swaminathan;I. Aranson
底物上细胞运动的计算建模是一个艰巨的挑战；调控途径是相互交织的，影响细胞运动的力量并不能完全量化。另外的挑战来自于需要描述移动的可变形细胞边界。在这里，我们提出了一个简单的数学模型，通过相场方法将细胞形状动力学耦合到描述肌动蛋白丝网络的平均方向（极化）的矢量场。该模型成功地再现了细胞运动的主要现象：运动的不连续开始，细胞形状的多样性和形状振荡。这一结果与最近关于角化细胞和细胞碎片运动的实验在定性上是一致的。这个简单的模型在很大程度上捕捉到了形状的不对称性，这可能对实验的解释有用。
Computational modelling of cell motility on substrates is a formidable challenge; regulatory pathways are intertwined and forces that influence cell motion are not fully quantified. Additional challenges arise from the need to describe a moving deformable cell boundary. Here, we present a simple mathematical model coupling cell shape dynamics, treated by the phase-field approach, to a vector field describing the mean orientation (polarization) of the actin filament network. The model successfully reproduces the primary phenomenology of cell motility: discontinuous onset of motion, diversity of cell shapes and shape oscillations. The results are in qualitative agreement with recent experiments on motility of keratocyte cells and cell fragments. The asymmetry of the shapes is captured to a large extent in this simple model, which may prove useful for the interpretation of experiments.