Surgical treatment and other regional treatments for colorectal cancer liver metastases.
Surgical treatment and other regional treatments for colorectal cancer liver metastases.
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DOI：
10.1634/theoncologist.4-3-197
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发表时间：
1999-06
期刊：
影响因子：
--
通讯作者：
Sam S. Yoon;Kenneth K. Tanabe
中科院分区：
文献类型：
--
作者：
Sam S. Yoon;Kenneth K. Tanabe
肝脏是结直肠癌最常见的远处转移部位。大约四分之一的结直肠癌肝转移患者没有其他转移部位，可以采用针对肝脏肿瘤的区域治疗。结直肠癌肝转移的手术切除可导致24%-38%的五年生存率，但只有少数患者适合切除。其他局部治疗，如冷冻手术，射频消融，肝动脉化疗，可提供给患者不可切除，但孤立的肝转移。这些治疗方法的疗效仍在确定中。对于大多数转移性结直肠癌扩散到肝脏以外的患者，全身化疗而不是区域治疗是更合适的选择。
The liver is the most common site of distant metastasis from colorectal cancer. About one-fourth of patients with liver metastases from colorectal cancer have no other sites of metastasis and can be treated with regional therapies directed toward their liver tumors. Surgical resection of colorectal cancer liver metastases can result in a 24%-38% five-year survival, but only a minority of patients are candidates for resection. Other regional therapies such as cryosurgery, radiofrequency ablation, and hepatic intra-arterial chemotherapy may be offered to patients with unresectable but isolated liver metastases. The efficacy of these treatments is still being determined. For most patients with spread of metastatic colorectal cancer beyond the liver, systemic chemotherapy rather than regional therapy is a more appropriate option.