[A role of the autonomic nervous system in cerebro-cardiac disorders].
[A role of the autonomic nervous system in cerebro-cardiac disorders].
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DOI：
10.17116/jnevro2017117111153-160
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发表时间：
2017-01-01
影响因子：
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通讯作者：
Shishkin, A N
中科院分区：
文献类型：
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作者：
Basantsova, N Yu;Tibekina, L M;Shishkin, A N
作者考虑了不同自主中枢神经系统区域的解剖/生理特征和作用，包括岛叶皮质、杏仁核复合体、前扣带皮层、腹内侧前额叶皮质、下丘脑和骨骺，参与心血管活动的调节。这些结构的损伤，例如由于脑血液循环的急性紊乱，导致先前完好的心肌出现心律失常，包括致命性心律失常；收缩和舒张功能障碍，脑心综合征框架内考虑的缺血性变化。在细胞水平上，自主神经调节紊乱导致儿茶酚胺兴奋性毒性、氧化应激和自由基心肌损伤。
The authors consider anatomical/physiological characteristics and a role of different autonomic CNS regions, including insula cortex, amygdala complex, anterior cingulate cortex, ventral medial prefrontal cortex, hypothalamus and epiphysis, involved in the regulation of cardiovascular activity. The damage of these structures, e.g., due to the acute disturbance of cerebral blood circulation, led to arrhythmia, including fatal arrhythmia, in previously intact myocardium; systolic and diastolic dysfunction, ischemic changes considered in the frames of cerebro-cardial syndrome. On the cellular level, the disturbance of autonomic regulation resulted in catechol amine excitotoxicity, oxidative stress and free radical myocardium injury.