Leptospirosis renal disease
Leptospirosis renal disease
复制标题
DOI：
10.1093/ndt/16.suppl_5.73
复制
发表时间：
2001-01-01
影响因子：
6.1
通讯作者：
Pan, MJ
中科院分区：
文献类型：
--
作者：
Yang, CW;Wu, MS;Pan, MJ
钩端螺旋体病是一种重新出现的传染病，影响了全世界的动物和人类。在钩端螺旋体病中可能会遇到多个器官的参与，并且早期肾脏受累非常普遍，其特征是肾小管肾小球肾炎和管状功能障碍。 1997年至1999年期间，所有12名在Chang Gung Memorial Hospital（Taiwan）诊断出的患者均出现急性肾衰竭，五名患者需要透析。 Shermani是在台湾遇到的主要血清，而Penicillin可能会大大挽救患者从多个器官衰竭中挽救患者。为了了解钩端螺旋体感染的管状损伤背后的机制，从致病性钩端螺旋体中提取的外膜蛋白（OMP）被培养中的管状细胞。我们的体外实验表明，致病性钩端螺旋体的OMS激活了核NF Kappab结合，并刺激下游诱导型一氧化氮（INOS），单核细胞趋化吸收剂蛋白-1（MCP-1）和肿瘤坏死因子-Alpha（TNF-Alpha）表达。这些结果表明，钩端螺旋体感染可能会通过外膜的毒性成分诱导肾小球肾小球肾炎，然后表达炎症基因。
Leptospirosis is a re-emerging infectious disease, affecting both animals and humans worldwide. Multiple organ involvement may be encountered in leptospirosis, and early renal involvement is very common, characterized by tubulo-interstitial nephritis and tubular dysfunction. All 12 patients diagnosed in Chang Gung Memorial Hospital (Taiwan) between 1997 and 1999 had acute renal failure, with five patients requiring dialysis. Leptospira shermani is the main serovar encountered in Taiwan, and penicillin may dramatically rescue patients from multiple organ failure provided it is given early. To understand the mechanism behind tubular injuries by leptospira infection, outer membrane proteins (OMPs) extracted from pathogenic leptospira were given to tubular cells in culture. Our in vitro experiment showed that OMPs of pathogenic leptospira activate nuclear NF kappaB binding and stimulate downstream inducible nitric oxide (iNOS), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) expression. These results indicate that leptospiral infection may induce tubulo-interstitial nephritis through a toxic component in the outer membrane followed by expression of inflammatory genes.