LifeTime and improving European healthcare through cell-based interceptive medicine.
LifeTime and improving European healthcare through cell-based interceptive medicine.
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DOI：
10.1038/s41586-020-2715-9
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发表时间：
2020-11
期刊：
影响因子：
64.8
通讯作者：
LifeTime Community Working Groups
中科院分区：
文献类型：
--
作者：
Rajewsky N;Almouzni G;Gorski SA;Aerts S;Amit I;Bertero MG;Bock C;Bredenoord AL;Cavalli G;Chiocca S;Clevers H;De Strooper B;Eggert A;Ellenberg J;Fernández XM;Figlerowicz M;Gasser SM;Hubner N;Kjems J;Knoblich JA;Krabbe G;Lichter P;Linnarsson S;Marine JC;Marioni JC;Marti-Renom MA;Netea MG;Nickel D;Nollmann M;Novak HR;Parkinson H;Piccolo S;Pinheiro I;Pombo A;Popp C;Reik W;Roman-Roman S;Rosenstiel P;Schultze JL;Stegle O;Tanay A;Testa G;Thanos D;Theis FJ;Torres-Padilla ME;Valencia A;Vallot C;van Oudenaarden A;Vidal M;Voet T;LifeTime Community Working Groups
在这里，我们描述了Lifetime Initiative，其目的是在复杂疾病的发作和进展期间跟踪，理解和靶向人类细胞，并以单细胞分辨率分析它们对治疗的反应。这一使命将通过单细胞多组学和成像、人工智能以及从健康到疾病进展过程中患者衍生的实验疾病模型的开发、整合和应用来实现。对大型分子和临床数据集的分析将确定分子机制，创建疾病进展的预测计算模型，并揭示新的药物靶点和治疗方法。将通过学术界、医院、患者协会、健康数据管理系统和行业之间的互动，实现以道德和以患者为中心的愿景为基础的及时发现和拦截疾病。这一策略在单细胞水平上应用于癌症、神经和神经精神疾病以及传染性、慢性炎症和心血管疾病的关键医学挑战，将在未来十年内在欧洲迎来基于细胞的拦截医学。LifeTime计划是一项雄心勃勃的多学科计划，旨在通过跟踪疾病过程中的个体人类细胞和对治疗的反应来改善医疗保健，以便在欧洲开发和实施基于细胞的拦截医学。
Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade. The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.
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影响因子：
64.8
作者：
Helmink BA;Reddy SM;Gao J;Zhang S;Basar R;Thakur R;Yizhak K;Sade-Feldman M;Blando J;Han G;Gopalakrishnan V;Xi Y;Zhao H;Amaria RN;Tawbi HA;Cogdill AP;Liu W;LeBleu VS;Kugeratski FG;Patel S;Davies MA;Hwu P;Lee JE;Gershenwald JE;Lucci A;Arora R;Woodman S;Keung EZ;Gaudreau PO;Reuben A;Spencer CN;Burton EM;Haydu LE;Lazar AJ;Zapassodi R;Hudgens CW;Ledesma DA;Ong S;Bailey M;Warren S;Rao D;Krijgsman O;Rozeman EA;Peeper D;Blank CU;Schumacher TN;Butterfield LH;Zelazowska MA;McBride KM;Kalluri R;Allison J;Petitprez F;Fridman WH;Sautès-Fridman C;Hacohen N;Rezvani K;Sharma P;Tetzlaff MT;Wang L;Wargo JA
通讯作者：
Wargo JA
DOI：
10.1038/nrg.2018.4
发表时间：
2018-05
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
Karczewski KJ;Snyder MP
通讯作者：
Snyder MP
影响因子：
46.9
作者：
Giladi, Amir;Cohen, Merav;Amit, Ido
通讯作者：
Amit, Ido
影响因子：
25
作者：
Grubman, Alexandra;Chew, Gabriel;Polo, Jose M.
通讯作者：
Polo, Jose M.
影响因子：
16
作者：
Cardozo Gizzi, Andres M.;Cattoni, Diego, I;Nollmann, Marcelo
通讯作者：
Nollmann, Marcelo