Regional distinctions in cortical bone mineral density measured by pQCT can predict alterations in material property at the tibial diaphysis of the Cynomolgus monkey
Regional distinctions in cortical bone mineral density measured by pQCT can predict alterations in material property at the tibial diaphysis of the Cynomolgus monkey
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DOI：
10.1016/j.bone.2005.08.012
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发表时间：
2006-02-01
期刊：
影响因子：
4.1
通讯作者：
Ohya, K
中科院分区：
文献类型：
--
作者：
Nonaka, K;Fukuda, S;Ohya, K
我们研究了周边定量计算机断层扫描测量的皮质骨矿物质密度（Ct.BMD）的区域差异是否与骨组织的异质性有关，以及区域Ct.BMD是否是骨材料性质变化的更好指标。从17只雌性成年食蟹猴（Macaca fascicularis;平均年龄16.8岁）中获得双侧睾丸。在确定Ct.左右胫骨的BMD相似，左胫骨用于骨组织形态计量学，右胫骨用于三点弯曲试验。后象限的Ct、BMD明显高于前象限。在骨组织形态计量分析中，所有参数（即，后区的平均骨单位面积、平均骨单位面积、骨单位密度、骨单位面积百分比[%On.Ar]、骨单位面积百分比[%On.B.Ar]、初始改建骨单位面积百分比[%Il.On.Ar]、继发性改建骨单位面积百分比[%Sd.On.Ar]、孔隙率和类骨质面积百分比均显著低于前区。结果表明，在同一横截面上，骨组织结构是不均匀的。骨密度与断裂应力呈正相关，与韧性呈负相关，而骨密度与弹性模量呈正相关。后向逐步多元回归分析表明，后Ct.BMD和总Ct.BMD是预测断裂应力和韧性的最佳变量，分别考虑到年龄。后区的%On.Ar、%On.B.Ar和%Il.On.Ar与弹性模量呈负相关。后环的%On.Ar、%On.B.Ar和%Sd.On.Ar离子与韧性呈正相关。这些结果表明，局部Ct.BMD测量有助于评估与A矿化程度相关的骨材料性质的变化。特别是，前、后和总Ct.BMD可分别用于预测胫骨骨干材料特性的变化。(c)2005年爱思唯尔公司All rights reserved.
We examined whether regional differences in cortical bone mineral density (Ct.BMD) measured by peripheral quantitative computed tomography is related to the heterogeneity of bone tissue and whether regional Ct.BMD is a better indicator of changes in bone material properties. Bilateral tibiae were obtained from 17 female adult Cynomolgus monkeys (Macaca fascicularis; mean age 16.8 years). After determining that Ct. BMD was similar between the right and left tibiae, the left tibiae were used for bone histomorphometry and the right for a three-point bending test. The Ct.BMD in the posterior quadrant was significantly higher than that in the anterior quadrant. In the bone histomorphometric analysis, all parameters (i.e., average osteonal area, average osteonal bone area, osteon population density, percent osteonal area [%On.Ar], percent osteonal bone area [%On.B.Ar], percent osteonal area of initial remodelingo [%Il.On.Ar], percent osteonal area of secondary remodeling [%Sd.On.Ar], porosity, and percent osteoid area in the posterior region) were significantly lower than those in the anterior region. The results indicated that in the same cross-section, bone tissue structure was heterogeneous. Both total- and posterior-Ct.BMD were positively correlated with breaking stress and negatively correlated with toughness, whereas anterior-Ct.BMD was positively Correlated with elastic modulus. Backward stepwise multiple regression analyses indicated that posterior-Ct.BMD and total-Ct.BMD were the best variables for predicting breaking stress and toughness, respectively, when age is taken into account. The %On.Ar, %On.B.Ar, and %Il.On.Ar in the posterior region were negatively correlated with elastic modulus. The %On.Ar, %On.B.Ar, and %Sd.On.Ar in the posterior re.-ion were positively correlated with toughness. These findings indicated that regional Ct.BMD measurement is useful to assess changes in the material properties of bone associated with the degree of A mineralization. In particular, anterior-, posterior-, and total-Ct.BMD can be used separately to predict changes in the material properties of the tibial diaphysis. (c) 2005 Elsevier Inc. All rights reserved.