Nickel-Catalyzed Suzuki-Miyaura Coupling of Heteroaryl Ethers with Arylboronic Acids
Nickel-Catalyzed Suzuki-Miyaura Coupling of Heteroaryl Ethers with Arylboronic Acids
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镍催化杂芳基醚与芳基硼酸的 Suzuki-Miyaura 偶联
DOI：
10.1021/jo4005537
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发表时间：
2013-05-17
影响因子：
3.6
通讯作者：
Jin, Zhong
中科院分区：
文献类型：
--
作者：
Li, Xiao-Jian;Zhang, Jin-Ling;Jin, Zhong
研究了镍催化芳基硼酸与杂芳醚的Suzuki-Miyaura偶联反应。苯酚C-O键的选择性活化是通过将其转化为相应的芳基2,4-二甲氧基-1,3,5-三嗪-6-基醚来实现的，其中芳基C-O键可以被廉价的空气稳定的NiCl2（dppf）作为催化剂选择性地裂解。这些容易获得的杂芳醚偶联证明了广泛官能团的耐受性。
Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids was described. Selective activation of the phenol C-O bonds was achieved by converting them into the corresponding aryl 2,4-dimethoxy-1,3,5-triazine-6-yl ethers, in which aryl C-O bond could be selectively cleaved with inexpensive, air-stable NiCl2(dppf) as a catalyst. Coupling of these readily accessible heteroaryl ethers proved tolerant of extensive functional groups.