Insulin and insulin-like growth factor in normal and pathological cardiovascular physiology.
Insulin and insulin-like growth factor in normal and pathological cardiovascular physiology.
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DOI：
10.1161/01.hyp.29.3.691
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发表时间：
1997-03
期刊：
影响因子：
8.3
通讯作者：
James R. Sowers
中科院分区：
文献类型：
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作者：
James R. Sowers
在过去的十年中，大量的数据表明，通常仅由胰腺分泌的胰岛素和由心血管系统细胞分泌的IGF-1调节正常的心血管生理反应。1 2 3 4 5 6 7 8 9 10 11日12日13日14日15 16 17 18 19 20 21日22日23日24日25日26日27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 101 102此外,那里是新兴的证据,异常行为的这些因素可能造成对疾病状态等是高血压和动脉粥样硬化。本文综述了目前对正常和病理条件下胰岛素和IGF-1对心血管组织的血流动力学、代谢和生长影响的机制的理解。
Over the past decade considerable data have been garnered suggesting that insulin, normally secreted only by the pancreas, and IGF-1, secreted by cells of the cardiovascular system, regulate normal cardiovascular physiological responses. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 101 102 Furthermore, there is emerging evidence that abnormal actions of these factors may contribute to disease states such as hypertension and atherosclerosis. 38 39 This review presents the current understanding of mechanisms of the hemodynamic, metabolic, and growth effects of insulin and IGF-1 exerted on cardiovascular tissue under both normal and pathological conditions.