FLUOXETINE-INDUCED INSULIN-LIKE GROWTH FACTOR-II (IGF-II) CHANGES IN HYPOTHALAMI OF NORMAL, EXERCISED AND FOOD RESTRICTED RATS
FLUOXETINE-INDUCED INSULIN-LIKE GROWTH FACTOR-II (IGF-II) CHANGES IN HYPOTHALAMI OF NORMAL, EXERCISED AND FOOD RESTRICTED RATS
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DOI：
10.1016/0167-0115(93)90332-3
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发表时间：
1993-10-20
影响因子：
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通讯作者：
ARAVICH, PF
中科院分区：
文献类型：
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作者：
LAUTERIO, TJ;RIEG, TS;ARAVICH, PF
下丘脑和垂体胰岛素样生长因子II（IGF-II）肽浓度受胰岛素和葡萄糖缺乏等代谢相关因素的差异调节。然而，其他代谢应激因素如限食或运动对下丘脑IGF-II浓度的影响仍有待进一步研究。为了评估代谢应激是否改变中枢神经系统IGF-II分泌，与运动匹配、体重匹配或自由进食对照相比，在表现出基于活动的厌食症（阿坝）的大鼠中进行肽分析。此外，通过测定IGF-II对氟西汀（FLX）注射（15 mg/kg体重，i.p.）。虽然阿坝和体重减轻改变外周IGF-II浓度相比，随意喂养或行使控制，这些治疗对下丘脑或垂体后叶IGF-II含量没有影响。然而，与注射溶剂相比，FLX给药增加了下丘脑腹内侧的IGF-II浓度，降低了下丘脑外侧的IGF-II含量。FLX还可降低垂体前叶IGF-II水平。这些数据表明，存在对CNS IGF-II的β-羟色胺能影响，并且影响5-羟色胺代谢或疗效的因素可能会改变IGF-II的分泌。
Hypothalamic and pituitary insulin-like growth factor II (IGF-II) peptide concentrations are differentially regulated by factors associated with metabolism such as insulin and glucoprivation. However, the effects of other metabolic stressors such as food restriction or exercise on hypothalamic IGF-II concentrations remain largely to be explored. In order to assess whether metabolic stress alters central nervous system IGF-II secretion, peptide analysis was conducted in rats exhibiting activity-based anorexia (ABA) compared to exercised-matched, body weight-matched or ad libitum fed controls. Further, the possibility of serotonergic control of IGF-II secretion was examined by determining IGF-II response to fluoxetine (FLX) injections (15 mg/kg body wt., i.p.). While ABA and body weight loss altered peripheral IGF-II concentrations compared to ad libitum fed or exercised controls, these treatments had no effect on hypothalamic or posterior pituitary IGF-II content. However, FLX administration increased IGF-II concentrations in the ventromedial hypothalamus and decreased IGF-II content in the lateral hypothalamus compared to vehicle injected. Anterior pituitary levels of IGF-II were also decreased by FLX. These data suggest that a serotonergic influence on CNS IGF-II exists and that IGF-II secretion may be altered by factors affecting serotonin metabolism or efficacy.