Biting suppresses stress-induced expression of corticotropin-releasing factor (CRF) in the rat hypothalamus
Biting suppresses stress-induced expression of corticotropin-releasing factor (CRF) in the rat hypothalamus
复制标题
DOI：
10.1177/154405910408300208
复制
发表时间：
2004-02-01
影响因子：
7.6
通讯作者：
Tamura, K
中科院分区：
文献类型：
--
作者：
Hori, N;Yuyama, N;Tamura, K
促肾上腺皮质激素释放因子(CRF)表达于下丘脑，在调节应激源的行为反应中起重要作用。抑制动物的身体已被证明激活和诱导大鼠下丘脑室旁神经元CRF的表达增强。由于攻击性咬合行为可以抑制应激诱导的中枢神经系统去甲肾上腺素的分泌和胃溃疡的形成，我们研究了咬合对束缚诱导的大鼠下丘脑CRF表达的影响。短时间束缚(30分钟或60分钟)后180分钟，室旁核CRF阳性神经元数量明显增加。束缚应激时咬木棍可显著抑制束缚诱导的室旁核CRF表达的增强。这些观察结果表明，咬合可能具有抗应激作用，而非功能性咀嚼活动在应对应激事件中起着重要作用。
Corticotropin-releasing factor (CRF) expressed in the hypothalamus plays an important role in mediating behavioral responses to stressors. Restraining the body of an animal has been shown to activate and induce an enhanced expression of CRF in paraventricular neurons of the rat hypothalamus. Since aggressive biting behavior is known to suppress stress-induced noradrenaline secretion in the central nervous system and the formation of gastric ulcers, we investigated the effect of biting on restraint-induced CRF expression in the rat hypothalamus. The number of CRF-expressing neurons in the paraventricular nucleus increased significantly after short time restraint (30 or 60 min) followed by a 180-minute post-restraint period. Biting of a wooden stick during the restraint stress significantly suppressed the restraint-induced enhancement of CRF expression in the paraventricular nucleus. These observations suggest a possible anti-stress effect of biting and an important role of para-functional masticatory activity in coping with stressful events.