High-resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population
High-resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population
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DOI：
10.1111/j.1399-0039.2006.00636.x
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发表时间：
2006-08-01
期刊：
影响因子：
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通讯作者：
Arguello, J. R.
中科院分区：
文献类型：
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作者：
Garcia-Ortiz, J. E.;Sandoval-Ramirez, L.;Arguello, J. R.
我们描述的第一次高分辨率分析HLA-A，-B，-C，-DRB 1，-DQB 1和-DPB 1在一个文化和地理上不同的墨西哥种族群体，塔拉乌马拉人。通过参考链介导的构象分析在该群体中最常发现的等位基因是1类：HLA-A*240201，*020101/09，*0206，*310102，*680102; HLA-B*4002，*1501，*510201，*3501/02/03，*4005，*4801; HLA-Cw*0304，*0801，*0102，*040101;和对于II类：HLA-DRB 1 *080201，*1402，*040701; HLA-DQBI*0402，*0301，*0302/07; HLA-DPBI*0402，*0401，*020102。此外，一个新的等位基因，HLA-A* 0257.Based上的比较，目前已知的HLA-DRB 1和-DQB 1等位基因频率在美洲印第安人群体和世界各地的人口，Tarahumaras出乎意料地更接近地理和语言上遥远的Aymara和Terena美洲印第安人群体比他们是邻近的部落。
We describe for the first time the high-resolution profiling of HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 in a culturally and geographically distinct Mexican ethnic group, the Tarahumaras. The alleles most frequently found by reference strand-mediated conformational analysis in this population were for class 1: HLA-A*240201, *020101/09, *0206, *310102, *680102; HLA-B*4002, *1501, *510201, *3501/02/03, *4005, *4801; HLA-Cw*0304, *0801, *0102, *040101; and for class II: HLA-DRBI*080201, *1402, *040701; HLA-DQBI*0402, *0301, *0302/07; HLA-DPBI*0402, *0401, *020102. In addition, a novel allele, HLA-A*0257, was found. Based on comparison of presently known HLA-DRB1 and -DQB1 allele frequencies in Amerindian groups and worldwide populations, the Tarahumaras are unexpectedly more related to the geographically and linguistically distant Aymara and Terena Amerindian groups than they are to neighbouring tribes.