IKK/NF-κB signaling in intestinal epithelial cells controls immune homeostasis in the gut
IKK/NF-κB signaling in intestinal epithelial cells controls immune homeostasis in the gut
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DOI：
10.1038/mi.2008.53
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发表时间：
2008-11-01
影响因子：
8
通讯作者：
Pasparakis, M.
中科院分区：
文献类型：
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作者：
Pasparakis, M.
肠道上皮不仅通过提供物理屏障，而且通过表达许多免疫调节和抗菌肽来调节共生菌与免疫系统之间的相互作用。最近的研究表明，体内肠道上皮细胞特异性抑制I κ B激酶(IKK)/核因子κ B （nf - κ B）信号可引起小鼠肠道炎症的自发发展。这些发现表明肠上皮细胞中的IKK/NF-kappa B信号是维持肠道上皮完整性和免疫稳态的重要因素。
The intestinal epithelium regulates the interaction between commensal bacteria and the immune system not only by providing a physical barrier but also by expressing a number of immunoregulatory and antimicrobial peptides. Recent studies showed that inhibition of I kappa B kinase (IKK)/nuclear factor-kappa B (NF-kappa B) signaling specifically in intestinal epithelial cells in vivo causes the spontaneous development of intestinal inflammation in mice. These findings identify IKK/NF-kappa B signaling in intestinal epithelial cells as an important factor for the maintenance of epithelial integrity and immune homeostasis in the gut.