BRAIN ACETYLCHOLINE - CONTROL BY DIETARY CHOLINE
BRAIN ACETYLCHOLINE - CONTROL BY DIETARY CHOLINE
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DOI：
10.1126/science.1251187
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发表时间：
1976-01-01
期刊：
影响因子：
56.9
通讯作者：
WURTMAN, RJ
中科院分区：
文献类型：
--
作者：
COHEN, EL;WURTMAN, RJ
大鼠全脑或不同脑区的乙酰胆碱浓度以及血清和脑中的游离胆碱浓度随膳食胆碱消耗量而变化。用毒扁豆碱（乙酰胆碱酯酶抑制剂）治疗后或食用高胆碱饮食后，大脑乙酰胆碱的增加是累加性的，表明胆碱通过增加乙酰胆碱的合成而发挥作用。
Acetylcholine concentrations in whole rat brain or in various brain regions and free choline concentrations in blood serum and brain vary with dietary choline consumption. The increases in brain acetylcholine after treatment with physostigmine (an inhibitor of acetylcholinesterase) or after consumption of a diet high in choline are additive, suggesting that choline acts by increasing acetylcholine synthesis.