Long-term morphology of a healing bone-tendon interface: a histological observation in the sheep model
Long-term morphology of a healing bone-tendon interface: a histological observation in the sheep model
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DOI：
10.1111/j.1469-7580.2007.00699.x
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发表时间：
2007-03-01
影响因子：
2.4
通讯作者：
Milburn, P.
中科院分区：
文献类型：
--
作者：
Newsham-West, R.;Nicholson, H.;Milburn, P.
本研究的目的是检查和描述手术复位后肌腱-骨界面长期生物重建所涉及的事件序列。在成年羊髌腱再附着被用来调查和描述的生物成分参与愈合和修复肌腱的附着点。在8、12、26、52和104周的时间间隔，使用光学显微镜来描述愈合形态。到8周时，在肌腱和骨之间观察到胶原连续体。随着时间的推移，这种纤维桥锚定到原始组织（肌腱和骨）中，所得的附着点更像纤维而不是原始的纤维软骨附着点。随着时间的推移，两种组织之间的相关胶原纤维在形态上逐渐改变，以反映原始肌腱组织中观察到的纤维。与对照组相比，形成的附着点的纤维组织保持细胞增生。由此产生的长期形态可能是功能适应的反映，而不是解剖复制。
The purpose of this study was to examine and describe the sequence of events involved in long-term biological reconstruction of a tendon-bone interface following surgical reattachment. Patellar tendon re-attachment in the adult sheep was used to investigate and describe the biological components involved in healing and repair of a tendon enthesis. Light microscopy was used to describe the healing morphology at time intervals of 8, 12, 26, 52 and 104 weeks. By 8 weeks a collagen continuum was observed between the tendon and bone. Over time this fibrous bridge became anchored into the original tissues (tendon and bone), with the resultant enthesis resembling more a fibrous rather than the original fibrocartilagenous enthesis. The associated collagen fibrils between the two tissues gradually changed in morphology over time to reflect the fibres seen in the original tendon tissue. The fibrous tissue of the forming enthesis remained hypercellular when compared with the controls. The resultant long-term morphology may be a reflection of functional adaptation rather than anatomical replication.