Good and evil, more reasons to study UPR
Good and evil, more reasons to study UPR
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善与恶，更多学习UPR的理由
DOI：
10.1016/j.kint.2022.09.015
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发表时间：
2023
影响因子：
19.6
通讯作者：
Hasegawa Sho
中科院分区：
文献类型：
--
作者：
Inagi Reiko;Hasegawa Sho
未折叠蛋白反应(UPR)途径由内质网启动，维持内质网的动态平衡。在肾脏疾病中，失调的UPR途径与疾病表型有关，如蛋白尿、炎症和纤维化。虽然越来越多的证据表明，UPR通路作为包括肾脏疾病在内的各种疾病的治疗靶点具有有益的影响，但对适应性UPR状态的控制仍然是疾病治疗的难点。这篇文章可能会给我们提供一个新的视角，以维持肾脏保护UPR途径的策略。
The unfolded protein response (UPR) pathway, launched by endoplasmic reticulum, maintains endoplasmic reticulum homeostasis. Dysregulated UPR pathway links disease phenotypes, such as proteinuria, inflammation, and fibrosis, in kidney disease. Although accumulating evidence indicates the beneficial impact of the UPR pathway as a therapeutic target for various diseases, including kidney disease, the control of adaptive UPR status is still difficult for disease treatment. This article may give us a new insight into the strategy for sustaining the kidney protective UPR pathway.