Thrombelastgram as a hemostatic monitor during recombinant factor VIIa treatment in hemophilia A patients with inhibitor to factor VIII.
Thrombelastgram as a hemostatic monitor during recombinant factor VIIa treatment in hemophilia A patients with inhibitor to factor VIII.
复制标题
血栓弹力图作为凝血因子 VIIa 治疗期间具有因子 VIII 抑制剂的甲型血友病患者的止血监测仪。
DOI：
10.1159/000217256
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
M. Shima
中科院分区：
文献类型：
--
作者：
Akira Yoshioka;K. Nishio;M. Shima
血栓弹力图 (TEG) 是一种古老但自动化的仪器，可显示血液凝固和纤维蛋白溶解过程中发生的变化。在 3 名具有高滴度凝血因子 VIII 抑制剂的 A 型血友病患者中使用重组凝血因子 VIIa (65-80 μg/kg) 时，TEG 被评估为优于活化部分凝血活酶时间 (APTT) 作为止血效果的监测指标。 TEG比APTT更合适，因为TEG的r、r+k和ma值在输注后至少4小时内归一化，而APTT不同程度地缩短并且并不总是维持在正常水平达4小时。
Thrombelastgram (TEG) is an old but automated instrument that demonstrates changes occurring during blood coagulation and fibrinolysis. TEG was evaluated to be better than activated partial thromboplastin time (APTT) as a monitor of hemostatic effects when using recombinant factor VIIa (65-80 mu g/kg) in 3 hemophilia A patients with a high titer of factor VIII inhibitors. TEG was more suitable than APTT, because r, r + k and ma values of TEG were normalized at least for 4 h after the infusion, whereas APTT was variably shortened and was not always maintained at a normal level for 4 h.