Varenicline is a smoking cessation drug that blocks alveolar expansion in mice intratracheally administrated porcine pancreatic elastase
Varenicline is a smoking cessation drug that blocks alveolar expansion in mice intratracheally administrated porcine pancreatic elastase
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DOI：
10.1016/j.jphs.2018.06.007
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发表时间：
2018-06-01
影响因子：
3.5
通讯作者：
Yamauchi, Atsushi
中科院分区：
文献类型：
--
作者：
Koga, Mitsuhisa;Kanaoka, Yuki;Yamauchi, Atsushi
戒烟是肺气肿和肺部炎症患者最有效的治疗方法。本研究的目的是检查伐尼克兰，一种戒烟药物，对肺气肿的猪胰弹性蛋白酶（PPE）吸入小鼠的影响。用伐尼克兰和α 7烟碱乙酰胆碱受体（nAChR）拮抗剂甲基甘草次酸（MLA）处理吸入PPE的小鼠5天和21天。伐尼克兰可明显改善PPE吸入小鼠的肺泡扩张和支气管肺泡灌洗液中的炎症反应。这些阻断作用被MLA抑制。我们的研究结果表明伐尼克兰可能具有抗炎特性，包括减少肺组织中的炎性细胞募集，以通过α 7 nAChR保护PPE诱导的肺泡扩张。(c)2018作者Elsevier B.V.代表日本药理学会制作和主办。
Smoking cessation is the most effective treatment in patients with emphysema and lung inflammation. The aim of the present study was to examine the effect of varenicline, a smoking cessation drug, on emphysema in porcine pancreatic elastase (PPE)-inhaled mice. PPE-inhaled mice were treated with varenicline and an alpha 7 nicotinic acetylcholine receptor (nAChR) antagonist, methyllycaconitine (MLA) for 5 and 21 days. Varenicline markedly ameliorated alveolar expansion and inflammatory response in bronchoalveolar lavage fluid in PPE-inhaled mice. These blocking effects were inhibited by MLA. Our findings demonstrate that varenicline likely has an anti-inflammatory property including reduced inflammatory cell recruitment in lung tissue to protect PPE-induced alveolar expansion via alpha 7 nAChR. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.