Self-Assembly of One- and Two-Dimensional Hemoprotein Systems by Polymerization through Heme-Heme Pocket Interactions
Self-Assembly of One- and Two-Dimensional Hemoprotein Systems by Polymerization through Heme-Heme Pocket Interactions
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DOI：
10.1002/anie.200804006
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Hayashi, Takashi
中科院分区：
文献类型：
--
作者：
Kitagishi, Hiroaki;Kakikura, Yasuaki;Hayashi, Takashi
超分子蛋白质聚合物：当血红素部分被引入到脱细胞色素 b562(H63C)突变体的表面时，通过非共价血红素-血红素口袋相互作用形成超分子聚合物。将血红素三联体作为枢轴分子引入蛋白质聚合物中，进一步形成了二维蛋白质网络结构，并通过轻拍模式原子力显微镜进行了可视化(见图)。
Supramolecular protein polymers: When a heme moiety was introduced to the surface of an apo‐cytochrome b562(H63C) mutant, supramolecular polymers formed through noncovalent heme–heme pocket interactions. The incorporation of a heme triad as a pivot molecule in the protein polymer further led to a two‐dimensional protein network structure, which was visualized by tapping‐mode atomic force microscopy (see picture).