p53 in signaling checkpoint arrest or apoptosis
p53 in signaling checkpoint arrest or apoptosis
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DOI：
10.1016/s0959-437x(96)90004-0
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发表时间：
1996-02-01
影响因子：
4
通讯作者：
Vousden, KH
中科院分区：
文献类型：
--
作者：
Bates, S;Vousden, KH
P53的细胞周期停滞和凋亡功能都有助于这种肿瘤抑制蛋白在防止受到DNA损伤的细胞复制方面的作用。尽管P53作为序列特异性转录因子的能力似乎与细胞周期G(1)阶段的停滞直接相关，但转录激活对细胞凋亡反应的贡献尚不清楚。似乎有几种P53活性，既有转录依赖的，也有转录独立的，可以在调节细胞死亡方面发挥作用。对这些功能的需求似乎取决于细胞类型、细胞环境和激活P53功能的细胞已经承受的其他遗传变化。
The cell cycle arrest and apoptotic functions of p53 both contribute to the role of this tumour suppressor protein in preventing replication of cells suffering DNA damage. Although the ability of p53 to function as a sequence-specific transcription factor appears to be directly and causally linked to the implementation of an arrest at the G(1) stage of the cell cycle, the contribution of transcriptional activation to the apoptotic response is less clear. It seems likely that several p53 activities, both transcriptionally dependent and transcriptionally independent, can play a role in mediating cell death. The requirement for each of these functions appears to depend on the cell type, the cell environment and other genetic alterations already sustained by the cell in which p53 function is activated.