Convergent and divergent mechanisms of sugar recognition across kingdoms.
Convergent and divergent mechanisms of sugar recognition across kingdoms.
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DOI：
10.1016/j.sbi.2014.07.003
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发表时间：
2014-10
影响因子：
6.8
通讯作者：
Drickamer, Kurt
中科院分区：
文献类型：
--
作者：
Taylor, Maureen E.;Drickamer, Kurt
碳水化合物识别结构域分为多个折叠家族。这些结构域中的许多都位于多结构域蛋白中，这些蛋白也具有其他活性。趋同进化导致了具有不同折叠的域中的共享特征。在生命王国中发现的家庭反映了广泛的不同进化。影响糖结合的多态反映了最近的进化压力。结合特定寡糖的蛋白质模块在从单细胞生物体到人类的所有生命王国中都能找到。蛋白质中糖结合结构域的不同、重叠和不断演变的名称有时会掩盖共同的特征，这些共同特征往往反映了区分具有密切相似结构的糖并以足够的亲和力结合它们以实现生物意义结果的问题的收敛解决方案。结构和功能分析表明，结构差异很大的蛋白质结构域与采用共同解决糖识别问题的进化历史之间有着惊人的相似之处。最近的研究还表明，通过不同进化从共同祖先进化而来的领域，在生命王国中出现的范围比以前所认识的更广泛。
Carbohydrate-recognition domains fall into multiple fold families. Many of these domains are in multidomain proteins that also have other activities. Convergent evolution has led to shared features in domains with different folds. Families found across the kingdoms of life reflect extensive divergent evolution. Polymorphisms that affect sugar binding reflect recent evolutionary pressure. Protein modules that bind specific oligosaccharides are found across all kingdoms of life from single-celled organisms to man. Different, overlapping and evolving designations for sugar-binding domains in proteins can sometimes obscure common features that often reflect convergent solutions to the problem of distinguishing sugars with closely similar structures and binding them with sufficient affinity to achieve biologically meaningful results. Structural and functional analysis has revealed striking parallels between protein domains with widely different structures and evolutionary histories that employ common solutions to the sugar recognition problem. Recent studies also demonstrate that domains descended from common ancestors through divergent evolution appear more widely across the kingdoms of life than had previously been recognized.
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影响因子：
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作者：
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