Resistance of Mice of the 129 Background to Yersinia pestis Maps to Multiple Loci on Chromosome 1.
Resistance of Mice of the 129 Background to Yersinia pestis Maps to Multiple Loci on Chromosome 1.
复制标题
129 背景小鼠对鼠疫耶尔森氏菌的抗性图谱位于 1 号染色体上的多个位点。
DOI：
10.1128/iai.00488-16
复制
发表时间：
2016
影响因子：
3.1
通讯作者：
Tapping,RichardI
中科院分区：
文献类型：
--
作者：
Tencati,Michael;Tapping,RichardI
Yersinia pestis is a Gram-negative bacterium that is the causative agent of bubonic and pneumonic plague. It is commonly acquired by mammals such as rodents and humans via the bite of an infected flea. We previously reported that multiple substrains of the 129 mouse background are resistant to pigmentation locus-negative (pgm−) Yersinia pestis and that this phenotype maps to a 30-centimorgan (cM) region located on chromosome 1. In this study, we have further delineated this plague resistance locus to a region of less than 20 cM through the creation and phenotyping of recombinant offspring arising from novel crossovers in this region. Furthermore, our experiments have revealed that there are at least two alleles in this initial locus, both of which are required for resistance on a susceptible C57BL/6 background. These two alleles work intranssince resistance is restored in offspring possessing one allele contributed by each parent. Our studies also indicated that the Slc11a1 gene (formerly known as Nramp1) located within the chromosome1 locus is not responsible for conferring resistance to 129 mice.
