A STUDY OF POST-NATAL GROWTH AND REMODELING OF BONE
A STUDY OF POST-NATAL GROWTH AND REMODELING OF BONE
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DOI：
10.1002/aja.1001100202
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发表时间：
1962-01-01
影响因子：
--
通讯作者：
ENLOW, DH
中科院分区：
文献类型：
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作者：
ENLOW, DH
骨骼的总体建模涉及微观结构的广泛和累积的变化。本研究的目的是描述和说明重塑变化的顺序，并展示组织学结构的细节如何相互关联。研究了来自不同年龄组的恒河猴和茜素处理的白鼠的代表性骨骼的纵向和横向连续切片。致密骨的复杂组织是重建和重塑过程的结果，其中涉及骨膜和骨内膜生长方向的反复逆转以及不同种类骨组织的形成。产生了由不同区域组成的多层皮质。骨组织类型的分布和区域的结构排列与区域重塑情况直接相关。总体重塑期间形状的局部变化和轴的移动涉及称为骨漂移的过程。远缘物种之间骨骼结构的差异是根据模型变化和生长速度差异来解释的。
The gross modeling of bone involves extensive and cumulative changes in microscopic structure. The purpose of this study is to describe and illustrate the sequence of remodeling changes and to show how details of histological structure are correlated. Longitudinal and transverse serial sections of representative bones from an age series of rhesus monkeys and alizarin-treated white rats were studied. The complex organization of compact bone is a result of reconstruction and remodeling processes which involve repeated reversals in direction of periosteal and endosteal growth and the formation of different varieties of bone tissue. A multi-layered cortex is produced which is composed of distinct zones. The distribution of bone tissue types and the architectural arrangement of zones are directly associated with regional remodeling circumstances. Local changes in shape and shifts in axis during gross remodeling involve a process termed osseous drift. Differences in bone structure between distantly related species are explained on the basis of modeling changes and differential rates of growth.