Correlation Analysis of HOX, ErbB and IGFBP Family Gene Expression in Ovarian Cancer
Correlation Analysis of HOX, ErbB and IGFBP Family Gene Expression in Ovarian Cancer
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DOI：
10.1080/07357900802074349
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Tait, David L.
中科院分区：
文献类型：
--
作者：
Bahrani-Mostafavi, Zahra;Tickle, Timothy L.;Tait, David L.
在癌症研究中利用微阵列基因表达数据具有识别参与恶性发展的失调细胞通路的能力。本研究探讨HOX、ErbB和IGFBP三个基因家族与卵巢癌发生的关系。这些家庭的利益，因为相似的染色体位置和他们的表达失调卵巢癌。更高层次的统计学差异分析微阵列数据在65个卵巢样本，以评估相关性和相关基因家族之间的关系。在这三个家族中发现了15个基因显著失调。在感兴趣的基因内部和之间发现了38个显著相关性。我们的数据表明，HOX，ErbB和IGFBP基因对之间的显着建模的关系可以提供洞察卵巢癌的潜在生物学机制。
Utilizing microarray gene expression data in cancer research possesses the ability to identify deregulated cellular pathways involved in malignant development. This study investigated the relationships of three gene families, HOX, ErbB and IGFBP, with regard to the development of ovarian cancer. These families were of interest because of similar chromosomal locations and their deregulated expression in ovarian cancer. Higher level statistics were used to differentially analyze microarray data in 65 ovarian samples to assess correlation and relationships among the gene families of interest. Fifteen genes in the three families were found to be significantly deregulated. Thirty-eight significant correlations were found within and between the genes of interest. Our data indicates that the significantly modeled relationships between HOX, ErbB and IGFBP gene pairs could provide insight into the underlying biological mechanisms in ovarian cancer.