ENDOGENOUS OPIATES DO NOT INFLUENCE GLUCOSE AND LIPID-METABOLISM IN RAT ADIPOCYTES
ENDOGENOUS OPIATES DO NOT INFLUENCE GLUCOSE AND LIPID-METABOLISM IN RAT ADIPOCYTES
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DOI：
10.1055/s-0029-1210768
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发表时间：
1988-08-01
期刊：
影响因子：
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通讯作者：
PFEIFFER, EF
中科院分区：
文献类型：
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作者：
HAUNER, H;GLATTING, G;PFEIFFER, EF
鸦片制剂β的作用-在离体大鼠脂肪细胞中研究了内啡肽、强啡肽、甲硫脑啡肽、亮脑啡肽、吗啡和阿片拮抗剂纳洛酮对葡萄糖代谢和脂解的影响。未发现供试品改变125 I-胰岛素结合。阿片类药物不影响2-脱氧葡萄糖摄取或葡萄糖掺入脂质。它们也没有表现出脂解活性。我们的结论是，内源性阿片类药物诱导的葡萄糖稳态的紊乱不是通过对外周葡萄糖代谢的影响介导的。
The effects of the opiates .beta.-endorphin, dynorphin, met-enkephalin, leu-endphalin, morphine and of the opiate-antagonist naloxone on glucose metabolism and lipolysis were studied in isolated rat adipocytes. None of the tested substances was found to alter 125I-Insulin binding. The opiates did not influence 2-deoxy-glucose uptake or glucose incorporation into lipids. They also did not exhibit a lipolytic activity. We conclude that the distrubances of glucose homeostatis induced by endogenous opiates are not mediated by an effect on peripheral glucose metabolism.