Characterization of pHEMA-based hydrogels that exhibit light-induced bactericidal effect via release of NO
Characterization of pHEMA-based hydrogels that exhibit light-induced bactericidal effect via release of NO
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DOI：
10.1007/s10856-009-3795-0
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发表时间：
2009-11-01
影响因子：
3.7
通讯作者：
Mascharak, Pradip K.
中科院分区：
文献类型：
--
作者：
Halpenny, Genevieve M.;Steinhardt, Rachel C.;Mascharak, Pradip K.
将光活化NO供体[Mn（PaPy 3）（NO）] ClO 4（1a）引入到基于HEMA的聚合物水凝胶中，并对亚硝基-聚合物共轭材料1a（x）中心点A HG和1a（x）中心点A HG（MB）进行了表征。这些材料的NO释放性能和抗菌能力与生长衰减剂，如过氧化氢和亚甲蓝（MB）的报告。由于亚硝酰基仅在暴露于光时释放NO，因此像1a（x）中心点A HG（MB）的材料可以用作在受控条件下递送NO的伤口敷料。
A light-activated NO donor, [Mn(PaPy3)(NO)]ClO4 (1a), has been incorporated into HEMA-based polymer hydrogel and the nitrosyl-polymer conjugate materials 1a(x) center dot A HG and 1a(x) center dot A HG(MB) have been characterized. The NO releasing properties and antibacterial capabilities of these materials in conjunction with growth attenuators such as hydrogen peroxide and methylene blue (MB) are reported. Since the nitrosyl releases NO only upon exposure to light, materials like 1a(x) center dot A HG(MB) could be used as wound dressings that deliver NO under controlled conditions.