Relayed hyperpolarization from para-hydrogen improves the NMR detectability of alcohols.
Relayed hyperpolarization from para-hydrogen improves the NMR detectability of alcohols.
复制标题
对位氢的中继超极化提高了醇的 NMR 检测能力。
DOI：
10.1039/c9sc02765c
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发表时间：
2019
期刊：
影响因子：
8.4
通讯作者：
Rayner PJ
中科院分区：
文献类型：
--
作者：
Rayner PJ
通过磁共振技术检测醇类对于它们的表征和化学变化的监测是重要的。超极化过程可以使以前不切实际的测量成为可能，例如低浓度中间体的测定。在这里，我们调查的SABRE-Relay方法，以确定其关键特性，并提高所得的1H NMR信号增益，随后接近103每质子。我们确定了最佳的胺质子转移剂SABRE-Relay，并显示催化剂结构如何影响结果。该方法的广度是通过扩展到更复杂的醇和异核的极化。
The detection of alcohols by magnetic resonance techniques is important for their characterization and the monitoring of chemical change. Hyperpolarization processes can make previously inpractical measurements, such as the determination of low concentration intermediates, possible. Here, we investigate the SABRE-Relay method in order to define its key characteristics and improve the resulting 1H NMR signal gains which subsequently approach 103 per proton. We identify optimal amine proton transfer agents for SABRE-Relay and show how catalyst structure influences the outcome. The breadth of the method is revealed by expansion to more complex alcohols and the polarization of heteronuclei.