From gut changes to type 2 diabetes remission after gastric bypass surgeries
From gut changes to type 2 diabetes remission after gastric bypass surgeries
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DOI：
10.1007/s11684-013-0258-2
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发表时间：
2013-04
影响因子：
8.1
通讯作者：
Bing Li;Xinrong Zhou;Jiarui Wu;Huarong Zhou
中科院分区：
文献类型：
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作者：
Bing Li;Xinrong Zhou;Jiarui Wu;Huarong Zhou
越来越多的证据表明，肠道可能影响宿主的新陈代谢，并最终改变 2 型糖尿病 (T2DM) 的结果。我们回顾了胃绕道手术后肠道与 T2DM 缓解之间关系的证据，并讨论了上述关系的潜在机制：肠道解剖结构重排、微生物组成变化、肠道细胞改变和肠道激素调节。然而，胃绕道手术后的确切变化及其在代谢改善中的相对重要性仍有待进一步阐明。阐明搭桥手术后 T2DM 消退的精确代谢机制将有助于揭示发病机制的分子机制，并促进针对这种常见疾病的新诊断和预防干预措施的发展。
Increasing evidence suggests that the gut may influence the host’s metabolism and ultimately change the outcomes of type 2 diabetes mellitus (T2DM). We review the evidence on the relationship between the gut and T2DM remission after gastric bypass surgery, and discuss the potential mechanisms underlying the above relationship: gut anatomical rearrangement, microbial composition changes, altered gut cells, and gut hormone modulation. However, the exact changes and their relative importance in the metabolic improvements after gastric bypass surgery remain to be further clarified. Elucidating the precise metabolic mechanisms of T2DM resolution after bypass surgery will help to reveal the molecular mechanisms of pathogenesis, and facilitate the development of novel diagnoses and preventative interventions for this common disease.