THE CRITICAL SIZE DEFECT AS AN EXPERIMENTAL-MODEL FOR CRANIOMANDIBULOFACIAL NONUNIONS
THE CRITICAL SIZE DEFECT AS AN EXPERIMENTAL-MODEL FOR CRANIOMANDIBULOFACIAL NONUNIONS
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DOI：
10.1097/00003086-198604000-00036
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发表时间：
1986-04-01
影响因子：
4.2
通讯作者：
HOLLINGER, JO
中科院分区：
文献类型：
--
作者：
SCHMITZ, JP;HOLLINGER, JO
在选择合适的颌面骨实验模型的问题上，研究者之间的观点并不一致。为了制定颌面骨不连的实验分析方案，我们回顾了以往以颅骨和下颌骨缺损为模型的研究。动物颅骨和下颌骨内骨不连的发生与大小有关。在动物的一生中不能愈合的大小缺陷被称为临界大小缺陷（CSDs）。假设在动物模型的层次结构中使用CSDs测试骨修复材料（BRMs）的基本原理。这一理论基础表明，应该先在大鼠和兔子的颅部进行试验，然后在狗和猴子的下颌骨进行试验。虽然已经在大鼠、兔和狗的颅骨中建立了CSD，但还需要进一步的研究来确定猴子颅骨中的CSD，以及狗和猴子下颌骨中的CSD。
Little consistency has been manifest among investigators in choosing an appropriate experimental model for maxillofacial bone research. In an effort to develop a protocol for the experimental analysis of maxillofacial nonunions, previous studies using calvarial and mandibular defects as models were reviewed. The creation of nonunions in animals within the calvaria and mandible was size dependent. Defects of a size that will not heal during the lifetime of the animal may be termed critical size defects (CSDs). A rationale was postulated for testing bone repair materials (BRMs) using CSDs in a hierarchy of animal models. This rationale suggests that testing should be initiated in the calvaria of the rat and rabbit, followed by testing in the mandibles of dogs and monkeys. While calvarial CSDs have been established in the rat, rabbit, and dog, further research is necessary to determine the CSD in the calvaria of the monkey, as well as the mandibles of dogs and monkeys.