Relation between in Utero Arsenic Exposure and Birth Outcomes in a Cohort of Mothers and Their Newborns from New Hampshire.
Relation between in Utero Arsenic Exposure and Birth Outcomes in a Cohort of Mothers and Their Newborns from New Hampshire.
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DOI：
10.1289/ehp.1510065
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发表时间：
2016-08
影响因子：
10.4
通讯作者：
Karagas MR
中科院分区：
文献类型：
--
作者：
Gilbert-Diamond D;Emond JA;Baker ER;Korrick SA;Karagas MR
研究表明，砷暴露会影响出生结果;然而，研究结果好坏参半。我们评估了子宫内砷暴露与出生结局的关系，以及母亲孕前体重和婴儿性别是否改变了这种关系。在706对通过饮用水和饮食暴露于低水平砷的母婴中，我们使用母亲中期妊娠尿砷、母亲孕前体重（通过自我报告）和出生结果（通过医疗记录）评估了子宫内砷暴露。尿总砷[tAs;无机砷（iAs）+单甲基胂酸（MMA）+二甲基胂酸（DMA）]的中位数（四分位距）为3.4 μg/L（1.7-6.0）。在校正的线性模型中，tAs每增加一倍与头围减少0.10 cm相关（95% CI：-0.19，-0.01）。MMA和DMA的结果相似。Ln（tAs）和ln（DMA）仅与男性婴儿的出生身长呈正相关;在男性中，tAs每增加一倍，出生身长增加0.28 cm（95% CI：0.09，0.46）（p相互作用= 0.04）。DMA的结果相似。此外，砷暴露与体重指数呈负相关，且相关性因母体体重而异。对于超重/肥胖的婴儿，tAs每增加一倍，体重指数降低0.55 kg/m3（95% CI：-0.82，-0.28，p < 0.001），而体重正常的婴儿则没有（p相互作用< 0.01）。最后，有一个显着的相互作用之间的母亲体重状况，婴儿性别，砷暴露对出生体重（pinteraction = 0.03）。在超重/肥胖母亲所生的女孩中，tAs每增加一倍与出生体重减少62.9 g相关（95% CI：-111.6，-14.2），尽管在其他分层中这种相关性为零。低水平的砷暴露可能会影响胎儿的生长，并可能修改的协会由母亲的体重状况和婴儿的性别。Gilbert-Diamond D，Emond JA，Baker ER，Korrick SA，Karagas MR. 2016.新罕布什尔州一组母亲及其新生儿宫内砷暴露与出生结局之间的关系环境健康展望124：1299-1307; http：dx.doi.org/10.1289/ehp.1510065
Studies suggest that arsenic exposure influences birth outcomes; however, findings are mixed. We assessed in utero arsenic exposure in relation to birth outcomes and whether maternal prepregnancy weight and infant sex modified the associations. Among 706 mother–infant pairs exposed to low levels of arsenic through drinking water and diet, we assessed in utero arsenic exposure using maternal second-trimester urinary arsenic, maternal prepregnancy weight through self-report, and birth outcomes from medical records. Median (interquartile range) of total urinary arsenic [tAs; inorganic arsenic (iAs) + monomethylarsonic acid (MMA) + dimethylarsinic acid (DMA)] was 3.4 μg/L (1.7–6.0). In adjusted linear models, each doubling of tAs was associated with a 0.10-cm decrease (95% CI: –0.19, –0.01) in head circumference. Results were similar for MMA and DMA. Ln(tAs) and ln(DMA) were positively associated with birth length in infant males only; among males, each doubling of tAs was associated with a 0.28-cm increase (95% CI: 0.09, 0.46) in birth length (pinteraction = 0.04). Results were similar for DMA. Additionally, arsenic exposure was inversely related to ponderal index, and associations differed by maternal weight. Each ln(tAs) doubling of tAs was associated with a 0.55-kg/m3 lower (95% CI: –0.82, –0.28, p < 0.001) ponderal index for infants of overweight/obese, but not normal-weight, mothers (pinteraction < 0.01). Finally, there was a significant interaction between maternal weight status, infant sex, and arsenic exposure on birth weight (pinteraction = 0.03). In girls born of overweight/obese mothers, each doubling of tAs was associated with a 62.9-g decrease (95% CI: –111.6, –14.2) in birth weight, though the association was null in the other strata. Low-level arsenic exposure may affect fetal growth, and the associations may be modified by maternal weight status and infant sex. Gilbert-Diamond D, Emond JA, Baker ER, Korrick SA, Karagas MR. 2016. Relation between in utero arsenic exposure and birth outcomes in a cohort of mothers and their newborns from New Hampshire. Environ Health Perspect 124:1299–1307; http://dx.doi.org/10.1289/ehp.1510065