Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome.
Self-Nucleic Acid Sensing: A Novel Crucial Pathway Involved in Obesity-Mediated Metaflammation and Metabolic Syndrome.
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DOI：
10.3389/fimmu.2020.624256
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发表时间：
2020
影响因子：
7.3
通讯作者：
Sisirak V
中科院分区：
文献类型：
--
作者：
Ferriere A;Santa P;Garreau A;Bandopadhyay P;Blanco P;Ganguly D;Sisirak V
肥胖和超重是影响世界近三分之一人口的全球性健康问题。肥胖有多种并发症，包括代谢综合征，通常会导致II型糖尿病和非酒精性脂肪性肝病的发展。代谢综合征和与肥胖相关的严重并发症的发生是由于代谢组织（如肝脏和白色脂肪组织）中发生的慢性低度炎症。近年来，在肥胖个体中系统性积累的核酸（主要是DNA）被证明会异常激活先天免疫反应，从而导致代谢组织炎症。这篇综述将聚焦于(i)肥胖期间积累的核酸的主要来源和形式，（ii）检测核酸所需的传感途径，以及（iii）参与这一过程的关键细胞参与者。充分阐明核酸在诱导肥胖引起的炎症中的作用将促进发现新的和期待已久的治疗方法，以限制肥胖介导的并发症。
Obesity and overweight are a global health problem affecting almost one third of the world population. There are multiple complications associated with obesity including metabolic syndrome that commonly lead to development of type II diabetes and non-alcoholic fatty liver disease. The development of metabolic syndrome and severe complications associated with obesity is attributed to the chronic low-grade inflammation that occurs in metabolic tissues such as the liver and the white adipose tissue. In recent years, nucleic acids (mostly DNA), which accumulate systemically in obese individuals, were shown to aberrantly activate innate immune responses and thus to contribute to metabolic tissue inflammation. This minireview will focus on (i) the main sources and forms of nucleic acids that accumulate during obesity, (ii) the sensing pathways required for their detection, and (iii) the key cellular players involved in this process. Fully elucidating the role of nucleic acids in the induction of inflammation induced by obesity would promote the identification of new and long-awaited therapeutic approaches to limit obesity-mediated complications.