An additive interaction between different qualities of dyspnea produced in normal human subjects
An additive interaction between different qualities of dyspnea produced in normal human subjects
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DOI：
10.1016/j.resp.2006.04.006
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发表时间：
2007-01-15
影响因子：
2.3
通讯作者：
Shinozuka, Norihiro
中科院分区：
文献类型：
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作者：
Nishino, Takashi;Isono, Shiroh;Shinozuka, Norihiro
我们通过视觉模拟评分（VAS）和使用23名健康受试者中列出的13个描述符，评估了单独高碳酸血症和高碳酸血症与血流阻力负荷联合引起的呼吸困难感觉。单独的高碳酸血症引起中度呼吸困难，其特征为空气饥饿和工作/努力感觉。增加吸气流量阻力负荷（IRL）导致吸气困难增加，做功/努力有所减弱。增加呼气流量阻力负荷（ERL）导致呼气困难增加和“空气饥饿”减弱。“IRL和ERL的增加导致呼吸困难显著增加，其数量接近IRL和ERL单独获得的增加之和，而呼吸困难的质量主要由工作/努力来表征。这些结果表明，尽管感觉质量不同，但当两种负荷同时出现时，呼吸困难的强度将线性相加。(c)2006 Elsevier B. V.保留所有权利。
We evaluated the sensation of dyspnea induced by hypercapnia alone and a combination of hypercapnia and flow-resistive loading by the use of visual analogue scale (VAS) and the use of 13 listed descriptors in 23 healthy subjects. Hypercapnia alone caused a modest degree of dyspnea characterized by both air hunger and work/effort sensations. An addition of inspiratory flow-resistive loading (IRL) caused an increase in inspiratory difficulty and some attenuation of 'work/effort.' The addition of expiratory flow-resistive loading (ERL) caused an increase in expiratory difficulty and attenuation of 'air hunger.' The addition of both IRL and ERL caused a marked increase in dyspnea, the amount of which was close to the sum of the increases obtained individually by IRL and by ERL, while the quality of dyspnea was characterized predominantly by work/effort. These results suggest that despite the difference in quality of sensations, the intensity of dyspnea would sum linearly when the two kinds of loads are presented at the same time. (c) 2006 Elsevier B.V. All rights reserved.