THE RELATION OF REPORTED ALCOHOL INGESTION TO PLASMA-LEVELS OF ESTROGENS AND ANDROGENS IN PREMENOPAUSAL WOMEN (MARYLAND, UNITED-STATES)
THE RELATION OF REPORTED ALCOHOL INGESTION TO PLASMA-LEVELS OF ESTROGENS AND ANDROGENS IN PREMENOPAUSAL WOMEN (MARYLAND, UNITED-STATES)
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DOI：
10.1007/bf01830726
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发表时间：
1994-01-01
影响因子：
2.3
通讯作者：
TAYLOR, PR
中科院分区：
文献类型：
--
作者：
DORGAN, JF;REICHMAN, ME;TAYLOR, PR
我们在马里兰州（美国）对107名绝经前妇女进行了一项关于酒精摄入和激素状态的横断面研究，以评估血浆激素水平是否可能介导酒精摄入和乳腺癌风险之间的正相关关系。酒精摄入量估计使用饮酒模式问卷，食物频率问卷，和七天的食物记录。在每个参与者月经周期的第5-7天、第12-15天和第21-23天收集空腹血液样本，并分别合并以产生卵泡期、周期中期和黄体期样本用于分析。雌酮，硫酸雌酮，雌二醇，雄烯二酮，硫酸脱氢表雄酮（DHEAS）的血浆中测定的放射免疫法，和性激素结合球蛋白（SHBG）测定的免疫放射分析。在调整了年龄、体重和总能量摄入后，酒精摄入与月经周期卵泡期、中期或黄体期的血浆雌激素水平无关，也与月经周期三个阶段的血浆SHBG或DHEAS水平无关。然而，酒精与血浆雄烯二酮的平均水平显著正相关。基于这些绝经前妇女的横断面研究结果，与酒精摄入相关的乳腺癌风险增加似乎不是由血浆雌激素水平升高介导的。然而，雄烯二酮可能介导酒精/乳腺癌相关性。
We undertook a cross-sectional study in 107 premenopausal women in Maryland (United States) of alcohol intake and hormonal status in order to evaluate whether plasma hormone levels might mediate the reported positive relation between alcohol ingestion and breast cancer risk. Alcohol ingestion was estimated using a drinking pattern questionnaire, a food frequency questionnaire, and seven-day food records. Fasting blood specimens were collected on days 5-7, 12-15, and 21-23 of each participant's menstrual cycle and pooled to create follicular, midcycle, and luteal phase samples, respectively, for analysis. Estrone, estrone sulfate, estradiol, androstenedione, and dehydroepiandrosterone sulfate (DHEAS) in plasma were measured by radioimmunoassay, and sex-hormone binding globulin (SHBG) was measured by an immunoradiometric assay. After adjusting for age, weight, and total energy intake, alcohol ingestion was not associated with plasma estrogens in the follicular, midcycle, or luteal phases of the menstrual cycle, nor with the level of SHBG or DHEAS in plasma averaged from the three phases of the cycle. Alcohol, however, was significantly positively associated with the average level of plasma androstenedione. Based on these cross-sectional findings among premenopausal women, the increased risk of breast cancer related to alcohol ingestion does not appear to be mediated by elevated plasma estrogen levels. Androstenedione, however, may mediate the alcohol/breast cancer-association.