Does prostaglandin D2 hold the cure to male pattern baldness?
Does prostaglandin D2 hold the cure to male pattern baldness?
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DOI：
10.1111/exd.12348
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发表时间：
2014-04
影响因子：
3.6
通讯作者：
Garza LA
中科院分区：
文献类型：
--
作者：
Nieves A;Garza LA
Lipids in the skin are the most diverse in the entire human body. Their bioactivity in health and disease is underexplored. Prostaglandin D2 has recently been identified as a factor which is elevated in the bald scalp of men with androgenetic alopecia and has the capacity to decrease hair lengthening. An enzyme which synthesizes it, prostaglandin D2 synthase (PTGDS or lipocalin-PGDS) is hormone responsive in multiple other organs. PGD2 has two known receptors, GPR44 and PTGDR. GPR44 was found to be necessary for the decrease in hair growth by PGD2. This creates an exciting opportunity to perhaps create novel treatments for androgenetic alopecia which inhibit the activity of PTGDS, PGD2 or GPR44. This review discusses the current knowledge surrounding PGD2 and future steps needed to translate these findings into novel therapies for patients with androgenetic alopecia.
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DOI：
10.1096/fj.12-218156
发表时间：
2013-02
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Khidhir KG;Woodward DF;Farjo NP;Farjo BK;Tang ES;Wang JW;Picksley SM;Randall VA
通讯作者：
Randall VA
影响因子：
15.9
作者：
Bell-Parikh, LC;Ide, T;FitzGerald, GA
通讯作者：
FitzGerald, GA
影响因子：
4.1
作者：
FINCHAM, N;CAMP, R
通讯作者：
CAMP, R
影响因子：
64.5
作者：
KLIEWER, SA;LENHARD, JM;LEHMANN, JM
通讯作者：
LEHMANN, JM
影响因子：
3.6
作者：
Colombe, Laurent;Vindrios, Armelle;Bernard, Bruno Alain
通讯作者：
Bernard, Bruno Alain