NEW ALKALOID AM-2282 OF STREPTOMYCES ORIGIN TAXONOMY, FERMENTATION, ISOLATION AND PRELIMINARY CHARACTERIZATION
NEW ALKALOID AM-2282 OF STREPTOMYCES ORIGIN TAXONOMY, FERMENTATION, ISOLATION AND PRELIMINARY CHARACTERIZATION
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DOI：
10.7164/antibiotics.30.275
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发表时间：
1977-01-01
影响因子：
3.3
通讯作者：
MASUMA, R
中科院分区：
文献类型：
--
作者：
OMURA, S;IWAI, Y;MASUMA, R
AM-2282是从链霉菌AM-2282中分离得到的一种新生物碱。该化合物在292 nm处具有最大吸收，并显示出对真菌和酵母的抗微生物活性。其盐酸盐的LD 50（小鼠腹腔注射）为6.6 mg/kg。AM-2282的分子式确定为C28 H26 N4 O3。AM-2282为一新种，命名为S. staurosporeus Awaya，Takahashi and Omura，nov. sp.
AM-2282, a new alkaloid was isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 was determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, S. staurosporeus Awaya, Takahashi and Omura, nov. sp. is proposed.